Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 5/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10267717 | 1.00 | MAOB (0.43) | MAOBPPARGMIFACHEBCHE | |
| SCHEMBL603907 | 0.89 | MAOB (0.48) | MAOBMIFACHEBCHEMTNR1B | |
| SCHEMBL603908 | 0.89 | MAOB (0.48) | MAOBMIFACHEBCHEMTNR1B | |
| SCHEMBL14673584 | 0.83 | CYP19A1 (0.43) | MAOBPPARGMTNR1AALDH1A1TDP1 | |
| SCHEMBL14673585 | 0.83 | CYP19A1 (0.43) | MAOBPPARGMTNR1AALDH1A1TDP1 | |
| SCHEMBL14685036 | 0.83 | CYP19A1 (0.43) | MAOBPPARGMTNR1AALDH1A1TDP1 | |
| SCHEMBL605776 | 0.80 | ACHE (0.52) | PPARGACHEMTNR1BMTNR1AALDH1A1 | |
| SCHEMBL626213 | 0.69 | ACHE (0.58) | MAOBACHECA1CA2MTNR1B | |
| SCHEMBL8765833 | 0.69 | ACHE (0.58) | ACHECA1CA2MTNR1BMTNR1A | |
| SCHEMBL603655 | 0.68 | ATM (0.45) | ACHECA1CA2MTNR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603481-A2 | AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | Abbott GmbH & Co. KG (DE) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012020131-A2 | AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY | ABBOTT GMBH & CO. KG (DE) | 2012-02-16 | — | — | WO | disclosed |