Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | PGR | P06401 | 3/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL625952 | 0.86 | LMNA (0.48) | MAOBLMNADYRK1ABRD4PGR | |
| SCHEMBL627485 | 0.85 | MAOB (0.39) | MAOBLMNADYRK1ABRD4PGR | |
| SCHEMBL12867047 | 0.80 | MAOB (0.51) | MAOBLMNADYRK1ABRD4PGR | |
| SCHEMBL626452 | 0.78 | PGR (0.42) | MAOBLMNADYRK1ABRD4PGR | |
| SCHEMBL12881773 | 0.73 | MAOB (0.52) | MAOBLMNADYRK1ABRD4PGR | |
| SCHEMBL11602317 | 0.72 | BLM (0.51) | MAOBLMNADYRK1ABRD4PGR | |
| SCHEMBL12727792 | 0.72 | MAOB (0.55) | MAOBLMNADYRK1ABRD4PGR | |
| Hydrochloric Acid SCHEMBL11601519 | 0.72 | BLM (0.50) | MAOBLMNADYRK1ABRD4PGR | |
| SCHEMBL14582468 | 0.71 | MAOB (0.53) | MAOBLMNADYRK1ABRD4PGR | |
| SCHEMBL20529102 | 0.71 | MAOB (0.53) | MAOBLMNADYRK1ABRD4PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | claimed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | claimed |