Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 8/20 | 0.68 |
| ▸ | TSHR | P16473 | 6/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.68 |
| ▸ | USP2 | O75604 | 1/20 | 0.68 |
| ▸ | TP53 | P04637 | 1/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21542308 | 0.87 | ALDH1A1 (0.65) | POLBLMNATSHRHSD17B10ALDH1A1 | |
| SCHEMBL13923614 | 0.85 | LMNA (0.67) | POLBLMNATSHRALDH1A1MAPK1 | |
| SCHEMBL27896818 | 0.84 | LMNA (0.71) | POLBLMNATSHRALDH1A1MAPK1 | |
| SCHEMBL6256297 | 0.84 | LMNA (0.71) | POLBLMNATSHRHSD17B10USP2 | |
| SCHEMBL5234744 | 0.83 | ALDH1A1 (0.67) | POLBLMNATSHRHSD17B10USP2 | |
| SCHEMBL631027 | 0.83 | LMNA (0.70) | POLBLMNATSHRALDH1A1MAPK1 | |
| SCHEMBL5235386 | 0.83 | ALDH1A1 (0.60) | POLBLMNATSHRHSD17B10ALDH1A1 | |
| SCHEMBL18701879 | 0.82 | LMNA (0.64) | POLBLMNATSHRHSD17B10ALDH1A1 | |
| SCHEMBL1464081 | 0.82 | LMNA (0.67) | POLBLMNATSHRHSD17B10ALDH1A1 | |
| SCHEMBL5231536 | 0.81 | LMNA (0.70) | POLBLMNATSHRHSD17B10USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005005382-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2005-01-20 | — | — | WO | disclosed |