Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | LIPC | P11150 | 3/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6256837 | 0.93 | MAPT (0.37) | LMNALIPCMAPTSMN1; SMN2TP53 | |
| SCHEMBL6258490 | 0.88 | CYP1A2 (0.42) | LIPCCYP3A4CYP2C9 | |
| SCHEMBL6613291 | 0.88 | CYP1A2 (0.42) | LIPCCYP3A4CYP2C9 | |
| SCHEMBL5901488 | 0.86 | CYP1A2 (0.42) | CYP3A4CYP2C9 | |
| SCHEMBL5965124 | 0.86 | CYP1A2 (0.42) | CYP3A4CYP2C9 | |
| SCHEMBL6261209 | 0.85 | DRD2 (0.37) | LIPCS1PR1GSK3BDYRK1AMET | |
| SCHEMBL6615762 | 0.85 | CYP3A4 (0.38) | LIPCTSHRSMN1; SMN2TP53S1PR1 | |
| SCHEMBL6617750 | 0.82 | LMNA (0.36) | LMNALIPCSPRMAPTTSHR | |
| SCHEMBL6185941 | 0.82 | LMNA (0.37) | LMNALIPCSPRMAPTTSHR | |
| SCHEMBL6259851 | 0.80 | CYP3A4 (0.39) | LIPCTSHRSMN1; SMN2TP53S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583760-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | CV Therapeutics Inc. (US) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004067506-A2 | SUBSTITUTED HETEROCYCLIC COMPOUNDS | CV THERAPEUTICS INC. (US) | 2004-08-12 | — | — | WO | disclosed |