Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 14/20 | 0.48 |
| ▸ | RARG | P13631 | 14/20 | 0.48 |
| ▸ | RARB | P10826 | 12/20 | 0.48 |
| ▸ | RARA | P10276 | 11/20 | 0.48 |
| ▸ | RXRB | P28702 | 9/20 | 0.48 |
| ▸ | RXRG | P48443 | 8/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6259442 | 1.00 | RXRA (0.48) | RXRARARGRARBRARARXRB | |
| SCHEMBL6260916 | 0.85 | RXRA (0.49) | RXRARARGRARBRARARXRB | |
| SCHEMBL6260911 | 0.85 | RXRA (0.49) | RXRARARGRARBRARARXRB | |
| SCHEMBL177719 | 0.81 | RXRA (0.73) | RXRARARGRARBRARARXRB | |
| SCHEMBL177720 | 0.81 | RXRA (0.73) | RXRARARGRARBRARARXRB | |
| SCHEMBL6428704 | 0.79 | RARB (0.54) | RXRARARGRARBRARARXRB | |
| SCHEMBL6261082 | 0.78 | RARG (0.52) | RXRARARGRARBRARARXRB | |
| SCHEMBL6261090 | 0.78 | RARG (0.52) | RXRARARGRARBRARARXRB | |
| SCHEMBL6428716 | 0.76 | RXRA (0.48) | RXRARARGRARBRARARXRB | |
| SCHEMBL6258868 | 0.72 | RARB (0.70) | RXRARARGRARBRARARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185277-B1 | Use of FXR synthetic ligands for the treatment of diseseas linked to cholesterol imbalance and colon cancer | ALLERGAN INC (US) | 2005-10-26 | — | — | EP | disclosed |
| US-6906057-B1 | Methods for modulating FXR receptor activity | ALLERGAN, INC. (US) | 2005-06-14 | — | — | US | disclosed |
| EP-1185539-B1 | ORGANOSILYL COMPOUNDS HAVING NUCLEAR HORMONE RECEPTOR MODULATING ACTIVITY | ALLERGAN INC (US) | 2004-12-01 | — | — | EP | disclosed |
| US-6452032-B1 | ANTAGONISTS, AGONISTS, OR INVERSE AGONISTS PARTICULARLY FOR RETINOID AND FARNESOID RECEPTORS; REGULATORS OF CELL PROLIFERATION AND DIFFERENTIATION AND OF LIPID METABOLISM; DERMATOSES SUCH AS ACNE, PSORIASIS, ICTHYOSIS AND ECZEMA | ALLERGAN SALES, LLC | 2002-09-17 | — | — | US | disclosed |