Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 12/20 | 0.74 |
| ▸ | MEN1 | O00255 | 8/20 | 0.74 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.71 |
| ▸ | CASP3 | P42574 | 4/20 | 0.64 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | CASP2 | P42575 | 1/20 | 0.60 |
| ▸ | CASP7 | P55210 | 1/20 | 0.60 |
| ▸ | CASP6 | P55212 | 1/20 | 0.60 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | KLK7 | P49862 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262680 | 0.90 | KMT2A (0.68) | KMT2AMEN1CTDSP1CASP3RXFP1 | |
| SCHEMBL6264004 | 0.87 | KMT2A (0.76) | KMT2AMEN1CTDSP1CASP3RXFP1 | |
| SCHEMBL12635988 | 0.85 | KMT2A (1.00) | KMT2AMEN1CTDSP1CASP3RXFP1 | |
| SCHEMBL12635981 | 0.85 | KMT2A (1.00) | KMT2AMEN1CTDSP1CASP3RXFP1 | |
| SCHEMBL6263607 | 0.85 | RXFP1 (0.75) | KMT2AMEN1CTDSP1CASP3RXFP1 | |
| SCHEMBL5637546 | 0.85 | MAPT (0.59) | KMT2AMEN1CTDSP1CASP3RXFP1 | |
| SCHEMBL6264128 | 0.85 | CASP3 (0.86) | KMT2AMEN1CTDSP1CASP3RXFP1 | |
| SCHEMBL22033257 | 0.82 | KMT2A (0.70) | KMT2AMEN1CTDSP1CASP3RXFP1 | |
| SCHEMBL13256678 | 0.82 | KMT2A (0.69) | KMT2AMEN1CTDSP1CASP3RXFP1 | |
| SCHEMBL6260500 | 0.82 | KMT2A (1.00) | KMT2AMEN1CTDSP1CASP3RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050182061-A1 | Phthalimide compounds useful as protein kinase inhibitors | GREEN JEREMY (US) | 2005-08-18 | — | — | US | claimed |
| WO-2005039564-A1 | PHTHALIMIDE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-05-06 | — | — | WO | claimed |
| US-20050182061-A1 | Phthalimide compounds useful as protein kinase inhibitors | GREEN JEREMY (US) | 2005-08-18 | — | — | US | disclosed |
| WO-2005039564-A1 | PHTHALIMIDE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050182061-A1 | Phthalimide compounds useful as protein kinase inhibitors | PDK1, PDPK1, MTOR | KMT2A 1256/4885MEN1 1849/4885CTDSP1 2132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.