Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1544806 | 0.91 | MEN1 (0.51) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6262281 | 0.90 | KMT2A (0.47) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6262295 | 0.87 | CYP3A4 (0.48) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1544484 | 0.83 | SMN1; SMN2 (0.54) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6264136 | 0.81 | KMT2A (0.48) | LMNAALDH1A1MEN1KMT2APTK2 | |
| SCHEMBL1544665 | 0.80 | KMT2A (0.52) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1543846 | 0.79 | BCHE (0.40) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL6261609 | 0.79 | CYP3A4 (0.45) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL3722568 | 0.79 | LMNA (0.49) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL1543917 | 0.78 | CYP3A4 (0.54) | MAPTLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005077345-A1 | COMPOUNDS FOR THE TREATMENT OF GASTRO-ESOPHAGEAL REFLUX DISEASE | ASTRAZENECA AB (SE) | 2005-08-25 | — | — | WO | claimed |