Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6262281 | 0.92 | KMT2A (0.47) | KMT2AATMALDH1A1LMNAHPGD | |
| SCHEMBL1544523 | 0.91 | KMT2A (0.52) | KMT2AATMALDH1A1LMNAHPGD | |
| SCHEMBL6261609 | 0.90 | CYP3A4 (0.45) | KMT2AATMALDH1A1LMNAHPGD | |
| SCHEMBL1544665 | 0.83 | KMT2A (0.52) | KMT2AATMALDH1A1LMNAHPGD | |
| SCHEMBL6259679 | 0.81 | MAPT (0.51) | KMT2AALDH1A1LMNAHDAC2PTK2 | |
| SCHEMBL1544484 | 0.81 | SMN1; SMN2 (0.54) | KMT2AALDH1A1LMNAHDAC2PTK2 | |
| SCHEMBL1545215 | 0.80 | KMT2A (0.42) | KMT2AATMALDH1A1LMNAHPGD | |
| SCHEMBL1544332 | 0.77 | KMT2A (0.52) | KMT2AATMALDH1A1LMNAHPGD | |
| SCHEMBL1543729 | 0.77 | LMNA (0.53) | KMT2AATMALDH1A1LMNATP53 | |
| SCHEMBL6262295 | 0.77 | CYP3A4 (0.48) | KMT2AALDH1A1LMNATP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005077345-A1 | COMPOUNDS FOR THE TREATMENT OF GASTRO-ESOPHAGEAL REFLUX DISEASE | ASTRAZENECA AB (SE) | 2005-08-25 | — | — | WO | claimed |