Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | TYK2 | P29597 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.35 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6890976 | 0.82 | KDM4E (0.56) | KDM4EHSD17B10JAK2JAK1TYK2 | |
| SCHEMBL7945632 | 0.77 | CNR2 (0.39) | KDM4ECNR2HTTALDH1A1RAB9A | |
| SCHEMBL2364958 | 0.75 | PDE2A (0.38) | KDM4EJAK2JAK1TYK2JAK3 | |
| SCHEMBL7048551 | 0.75 | KDM4E (0.37) | KDM4EHSD17B10KMT2ASMN1; SMN2HTT | |
| SCHEMBL731625 | 0.75 | ATM (0.56) | KDM4EHSD17B10KMT2ASMN1; SMN2HTT | |
| SCHEMBL732846 | 0.74 | ESR1 (0.54) | KMT2AHTTALDH1A1PDE6DALDH2 | |
| SCHEMBL2338761 | 0.73 | CYP2C9 (0.34) | KMT2AHTTMEN1CYP1A2CYP2C19 | |
| SCHEMBL29145105 | 0.72 | KDM4E (0.56) | KDM4EHSD17B10JAK2JAK1TYK2 | |
| SCHEMBL28646061 | 0.72 | ESR1 (0.52) | KDM4EHSD17B10JAK2JAK1TYK2 | |
| SCHEMBL2105982 | 0.72 | HSD17B10 (0.40) | KDM4EHSD17B10CNR2SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030206-A1 | ARYL-1,3-AZOLE DERIVATIVES AND METHODS FOR INHIBITING HEPARNASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-04-07 | — | — | WO | disclosed |