Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.47 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29145105 | 0.89 | KDM4E (0.56) | KDM4EHSD17B10CNR2KMT2ANPC1 | |
| SCHEMBL28646061 | 0.89 | ESR1 (0.52) | KDM4EHSD17B10CNR2KMT2ANPC1 | |
| SCHEMBL29145129 | 0.88 | KMT2A (0.61) | KDM4ECNR2KMT2ANPC1RAB9A | |
| SCHEMBL29145192 | 0.86 | TP53 (0.52) | KDM4EHSD17B10CNR2KMT2ANPC1 | |
| SCHEMBL6951818 | 0.86 | KDM4E (0.59) | KDM4EHSD17B10CNR2KMT2ANPC1 | |
| SCHEMBL29145131 | 0.84 | CNR2 (0.50) | KDM4EHSD17B10CNR2KMT2ANPC1 | |
| SCHEMBL29145102 | 0.84 | CASR (0.52) | KDM4EHSD17B10CNR2KMT2ANPC1 | |
| SCHEMBL29145098 | 0.84 | KDM4E (0.52) | KDM4EHSD17B10CNR2KMT2ANPC1 | |
| SCHEMBL1844163 | 0.83 | KDM4E (0.49) | KDM4EHSD17B10CNR2KMT2ANPC1 | |
| SCHEMBL29145109 | 0.83 | ALDH1A1 (0.64) | KDM4ECNR2KMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1391457-A1 | Substituted 2-Phenylbenzimidazoles and their use as PARP inhibitors | Abbott GmbH & Co. KG (DE) | 2004-02-25 | — | — | EP | disclosed |