SCHEMBL6259801

SCHEMBL6259801

COc1cccc(CNC(=O)c2cc3c(=O)n(Cc4ccc(OC(F)(F)F)cc4)c(=O)n(C)c3s2)c1.Cn1c(=O)n(Cc2ccc(C(=O)O)cc2)c(=O)c2cc(C(=O)NCCc3ccncc3)sc21

nearest known ligand 0.44

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.44
TP53 P04637 1/20 0.44
ROCK2 O75116 8/20 0.44
MMP13 P45452 5/20 0.43
GAA P10253 1/20 0.43
ROCK1 Q13464 3/20 0.42
TRPA1 O75762 2/20 0.42
CYP3A4 P08684 2/20 0.41
CYP2C9 P11712 2/20 0.41
PTGER4 P35408 2/20 0.41
CYP2D6 P10635 1/20 0.41
PRKACA P17612 1/20 0.41
GSK3A P49840 1/20 0.41
GSK3B P49841 1/20 0.41
PRKX P51817 1/20 0.41
PRKCQ Q04759 1/20 0.41
CLK4 Q9HAZ1 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6258396 0.88 MAPT (0.51) MAPTTP53ROCK2MMP13GAA
SCHEMBL6916309 0.86 MMP13 (0.55) MAPTTP53ROCK2MMP13GAA
SCHEMBL6916681 0.84 TRPA1 (0.46) MAPTTP53MMP13TRPA1GSK3A
SCHEMBL6280233 0.81 MAPT (0.51) MAPTTP53ROCK2MMP13GAA
SCHEMBL6433450 0.81 PPARA (0.53) MAPTTP53ROCK2GAATRPA1
SCHEMBL7032109 0.81 MAPT (0.54) MAPTTP53GAACYP3A4
SCHEMBL6474162 0.81 MAPT (0.56) MAPTTP53ROCK2GAATRPA1
SCHEMBL6728256 0.81 TRPA1 (0.56) MAPTMMP13TRPA1
SCHEMBL6462371 0.80 MMP13 (0.52) MAPTMMP13TRPA1PTGER4
SCHEMBL7032494 0.80 CLK1 (0.53) MAPTTP53GAACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1536786-A1 COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2005-06-08 EP disclosed
EP-1531904-A1 COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 THAT IS NOT CELECOXIB OR VALDECOXIB Warner-Lambert Company LLC (US) 2005-05-25 EP disclosed
WO-2004007024-A1 COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH A SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 THAT IS NOT CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed
WO-2004006913-A1 COMBINATION OF AN ALLOSTERIC INHIBITOR OF MATRIX METALLOPROTEINASE-13 WITH CELECOXIB OR VALDECOXIB WARNER-LAMBERT COMPANY LLC (US) 2004-01-22 WO disclosed