Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 19/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624866 | 0.90 | PIK3CA (0.46) | MAPTTHRBLMNAPOLBTP53 | |
| SCHEMBL626006 | 0.88 | PIK3CA (0.46) | MAPTTHRBLMNATP53PIK3CA | |
| SCHEMBL624870 | 0.85 | MAPT (0.42) | MAPTTHRBLMNAPOLBTP53 | |
| SCHEMBL627328 | 0.82 | PIK3CA (0.44) | PIK3CA | |
| SCHEMBL625178 | 0.82 | MAPT (0.54) | MAPTTHRBLMNAPOLBTP53 | |
| SCHEMBL624634 | 0.82 | MAPT (0.52) | MAPTTHRBLMNAPOLBTP53 | |
| SCHEMBL624991 | 0.82 | SYK (0.45) | PIK3CA | |
| SCHEMBL625223 | 0.82 | MAPT (0.49) | MAPTTHRBLMNAPOLBTP53 | |
| SCHEMBL626392 | 0.82 | MAP3K12 (0.44) | MAPTTHRBLMNAPOLBTP53 | |
| SCHEMBL625019 | 0.81 | MAP3K12 (0.45) | MAPTTHRBLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020215-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |