Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 13/20 | 1.00 |
| ▸ | MMP2 | P08253 | 3/20 | 0.81 |
| ▸ | MMP3 | P08254 | 3/20 | 0.81 |
| ▸ | MMP7 | P09237 | 3/20 | 0.81 |
| ▸ | MMP12 | P39900 | 2/20 | 0.81 |
| ▸ | MMP10 | P09238 | 2/20 | 0.81 |
| ▸ | MMP9 | P14780 | 1/20 | 0.81 |
| ▸ | MMP8 | P22894 | 1/20 | 0.81 |
| ▸ | MMP13 | P45452 | 1/20 | 0.81 |
| ▸ | MMP14 | P50281 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6789205 | 1.00 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP12 | |
| SCHEMBL6260124 | 1.00 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP12 | |
| SCHEMBL6260106 | 1.00 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP12 | |
| SCHEMBL6791287 | 0.93 | ADAM17 (0.86) | ADAM17MMP2MMP3MMP7MMP12 | |
| SCHEMBL6791356 | 0.91 | ADAM17 (1.00) | ADAM17MMP2MMP3MMP7MMP12 | |
| SCHEMBL6790054 | 0.90 | ADAM17 (0.82) | ADAM17MMP2MMP3MMP7MMP12 | |
| SCHEMBL6791369 | 0.90 | ADAM17 (0.82) | ADAM17MMP2MMP3MMP7MMP12 | |
| SCHEMBL5898489 | 0.90 | MMP2 (1.00) | ADAM17MMP2MMP3MMP7MMP12 | |
| SCHEMBL7430026 | 0.88 | ADAM17 (0.86) | ADAM17MMP2MMP3MMP7MMP12 | |
| SCHEMBL6790903 | 0.88 | ADAM17 (0.79) | ADAM17MMP2MMP3MMP7MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427408-A4 | CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$g(a) CONVERTING ENZYME (TACE) | BRISTOL MYERS SQUIBB CO (US) | 2005-10-26 | — | — | EP | disclosed |
| EP-1427408-A2 | CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-$g(a) CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-16 | — | — | EP | disclosed |
| WO-2003024899-A2 | CYCLIC HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-α CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |