Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 10/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.45 |
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | MMP7 | P09237 | 2/20 | 0.45 |
| ▸ | ADAMTS1 | Q9UHI8 | 2/20 | 0.45 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.45 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6265449 | 0.96 | ADAM17 (0.49) | ADAM17ADAMTS4MMP3MMP7ADAMTS1 | |
| SCHEMBL6265415 | 0.96 | ADAM17 (0.49) | ADAM17ADAMTS4MMP3MMP7ADAMTS1 | |
| SCHEMBL6261765 | 0.89 | ADAM17 (0.47) | ADAM17ADAMTS4MMP2 | |
| SCHEMBL6260459 | 0.88 | ADAM17 (0.53) | ADAM17ADAMTS4MMP3MMP7ADAMTS1 | |
| SCHEMBL6266539 | 0.86 | ADAM17 (0.57) | ADAM17MMP2MMP12 | |
| SCHEMBL6264308 | 0.79 | ADAM17 (0.56) | ADAM17MMP2MMP12 | |
| SCHEMBL6261752 | 0.75 | ADAM17 (0.51) | ADAM17MMP3MMP2MMP12 | |
| SCHEMBL6267486 | 0.73 | ADAM17 (0.51) | ADAM17ADAMTS4MMP2 | |
| SCHEMBL6212594 | 0.72 | ADAM17 (0.63) | ADAM17KDM4EMMP3MMP2MMP12 | |
| SCHEMBL5884640 | 0.72 | ADAM17 (0.69) | ADAM17ADAMTS4MMP3MMP7ADAMTS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005085232-A1 | HYDANTOIN DERIVATIVES FOR USE AS TACE AND AGGRECANASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-09-15 | — | — | WO | disclosed |