Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 10/20 | 0.56 |
| ▸ | MMP13 | P45452 | 3/20 | 0.53 |
| ▸ | MMP12 | P39900 | 2/20 | 0.52 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6266539 | 0.90 | ADAM17 (0.57) | ADAM17MMP12MMP2 | |
| SCHEMBL6267486 | 0.85 | ADAM17 (0.51) | ADAM17MMP13MMP2 | |
| SCHEMBL6261752 | 0.82 | ADAM17 (0.51) | ADAM17MMP12MMP2 | |
| SCHEMBL6260459 | 0.81 | ADAM17 (0.53) | ADAM17MMP12MMP2 | |
| SCHEMBL1504715 | 0.80 | ADAM17 (0.64) | ADAM17MMP13MMP12MMP2 | |
| SCHEMBL5887895 | 0.79 | ADAM17 (0.61) | ADAM17MMP13MMP12MMP2 | |
| SCHEMBL6265449 | 0.79 | ADAM17 (0.49) | ADAM17MMP12MMP2 | |
| SCHEMBL6260460 | 0.79 | ADAM17 (0.49) | ADAM17MMP12MMP2 | |
| SCHEMBL6632245 | 0.79 | ADAM17 (0.63) | ADAM17MMP13MMP12MMP2 | |
| SCHEMBL6598965 | 0.79 | ADAM17 (0.63) | ADAM17MMP12MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005085232-A1 | HYDANTOIN DERIVATIVES FOR USE AS TACE AND AGGRECANASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-09-15 | — | — | WO | disclosed |