Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.78 |
| ▸ | MMP9 | P14780 | 4/20 | 0.78 |
| ▸ | MMP8 | P22894 | 4/20 | 0.78 |
| ▸ | MMP13 | P45452 | 4/20 | 0.78 |
| ▸ | CHEK2 | O96017 | 14/20 | 0.73 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.66 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.65 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6264473 | 0.89 | CHEK2 (0.62) | MMP2MMP9MMP8MMP13CHEK2 | |
| SCHEMBL20982670 | 0.87 | CHEK2 (0.86) | CHEK2PKN1PKN2 | |
| SCHEMBL27528263 | 0.84 | MEN1 (0.74) | CHEK2PKN1PKN2 | |
| Terephthalamide SCHEMBL28143925 | 0.83 | CHEK2 (0.75) | CHEK2PKN1PKN2 | |
| SCHEMBL6259634 | 0.83 | CHEK2 (0.82) | CHEK2PKN1PKN2 | |
| SCHEMBL2339157 | 0.82 | MMP2 (0.84) | MMP2MMP9MMP8MMP13CHEK2 | |
| SCHEMBL24312910 | 0.81 | PLAU (0.71) | CHEK2PKN1PKN2 | |
| SCHEMBL29557707 | 0.81 | PLAU (0.71) | CHEK2PKN1PKN2 | |
| SCHEMBL6260769 | 0.81 | MMP2 (1.00) | MMP2MMP9MMP8MMP13CHEK2 | |
| SCHEMBL6243391 | 0.80 | CHEK2 (0.80) | CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030206-A1 | ARYL-1,3-AZOLE DERIVATIVES AND METHODS FOR INHIBITING HEPARNASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-04-07 | — | — | WO | disclosed |