Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11127254 | 0.90 | SMN1; SMN2 (0.61) | MAPTKDM4EKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6074318 | 0.82 | PTGS1 (0.57) | MAPTKDM4EKMT2ASMN1; SMN2TSHR | |
| SCHEMBL12663858 | 0.82 | MAPT (0.58) | MAPTMAPK1KDM4ETDP1KMT2A | |
| SCHEMBL6074194 | 0.82 | PTGS1 (0.57) | MAPTKDM4EKMT2ASMN1; SMN2TSHR | |
| SCHEMBL1496796 | 0.82 | MAPK1 (0.59) | MAPTMAPK1KDM4ETDP1KMT2A | |
| SCHEMBL18991198 | 0.82 | MAPT (0.58) | MAPTMAPK1KDM4ETDP1KMT2A | |
| SCHEMBL1496588 | 0.82 | MAPT (0.58) | MAPTMAPK1KDM4ETDP1KMT2A | |
| SCHEMBL16314627 | 0.81 | SMN1; SMN2 (0.53) | MAPTKDM4EKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10770337 | 0.81 | SMN1; SMN2 (0.53) | MAPTKDM4EKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1496558 | 0.81 | MAPT (0.57) | MAPTMAPK1KDM4ETDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11795169-B2 | MAP4K4 inhibitors | IMPERIAL COLLEGE INNOVATIONS LIMITED (GB) | 2023-10-24 | — | — | US | disclosed |
| US-6962945-B2 | N-aryloxypropanolyl-N′-phenethyl-urea | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-11-08 | — | — | US | disclosed |
| US-20050215631-A1 | NOVEL N-ARYLOXYPROPANOLYL-N' - PHENETHYL - UREA | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2005-09-29 | — | — | US | disclosed |
| WO-2005063699-A1 | N-ARYLOXYPROPANOLYL-N’-PHENETHYL-UREA | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215631-A1 | NOVEL N-ARYLOXYPROPANOLYL-N' - PHENETHYL - UREA | NPY4R, GPR119, MC4R | MAPT 4471/4885MAPK1 2184/4885KDM4E 84/4885 |
| US-11795169-B2 | MAP4K4 inhibitors | MAP4K4, MAP4K2, MAP4K5 | MAPT 315/4885MAPK1 31/4885KDM4E 742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.