Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 8/20 | 0.67 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.67 |
| ▸ | CXCL8 | P10145 | 4/20 | 0.67 |
| ▸ | TTR | P02766 | 3/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.67 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.67 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.67 |
| ▸ | UGT1A9 | O60656 | 1/20 | 0.67 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.67 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.67 |
| ▸ | ALB | P02768 | 1/20 | 0.67 |
| ▸ | UGT1A6 | P19224 | 1/20 | 0.67 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.67 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.67 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.67 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.67 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.67 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11200912 | 0.84 | CA12 (0.59) | PTGS2CXCL8TTRPTGS1ABCB11 | |
| Diclofenac SCHEMBL10797064 | 0.83 | PTGS2 (0.76) | PTGS2CXCL8TTRPTGS1ABCB11 | |
| Diclofenac SCHEMBL15665994 | 0.82 | PTGS2 (0.84) | PTGS2CXCL8TTRPTGS1ABCB11 | |
| Diclofenac SCHEMBL2799 | 0.82 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1ABCB11 | |
| Diclofenac SCHEMBL996716 | 0.82 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1ABCB11 | |
| Diclofenac SCHEMBL29354260 | 0.82 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1ABCB11 | |
| Diclofenac SCHEMBL10797667 | 0.82 | PTGS2 (0.74) | PTGS2CXCL8TTRPTGS1ABCB11 | |
| SCHEMBL11215604 | 0.82 | PTGS2 (0.56) | PTGS2CXCL8TTRPTGS1ABCB11 | |
| SCHEMBL11215996 | 0.82 | PTGS2 (0.56) | PTGS2CXCL8TTRPTGS1ABCB11 | |
| Diclofenac SCHEMBL27984058 | 0.81 | PTGS2 (0.86) | PTGS2CXCL8TTRPTGS1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101433544-B | External-use pharmaceutical composition formulation with antiphlogistic, swelling-dispersing and analgesic functions, and use | JIANGSU ZEUKOV PHARMACEUTICAL SCIENCE & TECHNOLOGY INC | 2012-07-18 | — | — | CN | claimed |
| CN-101433544-A | External-use pharmaceutical composition formulation with antiphlogistic, swelling-dispersing and analgesic functions, and use | JIANGSU ZEUKOV PHARMACEUTICAL (CN) | 2009-05-20 | — | — | CN | claimed |
| US-4593044-A | Lysinate salt of naproxen, ketoprofen or diclofenac | MERCKLE GMBH (DE) | 1986-06-03 | — | — | US | claimed |
| WO-2015176848-A1 | SELF-DRYING DOSAGE FORM WITH CONTROLLABLE DRYING TIME AND DRYING RATE | BAUER K H (DE) | 2015-11-26 | — | — | WO | disclosed |
| CN-101433544-B | External-use pharmaceutical composition formulation with antiphlogistic, swelling-dispersing and analgesic functions, and use | JIANGSU ZEUKOV PHARMACEUTICAL SCIENCE & TECHNOLOGY INC | 2012-07-18 | — | — | CN | disclosed |
| CN-101186583-B | Methyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate and its synthesizing method and application | UNIV JILIN | 2011-05-11 | — | — | CN | disclosed |
| CN-101433544-A | External-use pharmaceutical composition formulation with antiphlogistic, swelling-dispersing and analgesic functions, and use | JIANGSU ZEUKOV PHARMACEUTICAL (CN) | 2009-05-20 | — | — | CN | disclosed |
| CN-101186583-A | Methyl 2-(2-(2,6-dichlorophenylamino)phenyl)acetate and its synthesizing method and application | UNIV JILIN (CN) | 2008-05-28 | — | — | CN | disclosed |
| EP-1588697-A1 | Emulsion gel for topical application of pharmaceuticals | Bauer, Kurt H., Prof. Dr. (DE) | 2005-10-26 | — | — | EP | disclosed |
| CN-1452979-A | Medicine composition with anti-inflammatory effect and its production process | GUANGXI BIOCHEMICAL TECHN INST (CN) | 2003-11-05 | — | — | CN | disclosed |
| US-4593044-A | Lysinate salt of naproxen, ketoprofen or diclofenac | MERCKLE GMBH (DE) | 1986-06-03 | — | — | US | disclosed |
| US-4593044-A | Lysinate salt of naproxen, ketoprofen or diclofenac | MERCKLE GMBH (DE) | 1986-06-03 | — | — | US | disclosed |