Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 8/20 | 1.00 |
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 1.00 |
| ▸ | CXCL8 | P10145 | 4/20 | 1.00 |
| ▸ | TTR | P02766 | 3/20 | 1.00 |
| ▸ | AKR1B10 | O60218 | 1/20 | 1.00 |
| ▸ | UGT1A9 | O60656 | 1/20 | 1.00 |
| ▸ | TRPA1 | O75762 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | MT-CO2 | P00403 | 1/20 | 1.00 |
| ▸ | ALB | P02768 | 1/20 | 1.00 |
| ▸ | UGT1A6 | P19224 | 1/20 | 1.00 |
| ▸ | UGT1A1 | P22309 | 1/20 | 1.00 |
| ▸ | CXCR1 | P25024 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | AGTR2 | P50052 | 1/20 | 1.00 |
| ▸ | NR1I3 | Q14994 | 1/20 | 1.00 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 1.00 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 1.00 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 1.00 |
| ▸ | UGT1A10 | Q9HAW8 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diclofenac SCHEMBL29354260 | 1.00 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL2799 | 1.00 | PTGS2 (1.00) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL2216520 | 0.98 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL418230 | 0.98 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL4614418 | 0.98 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL1178502 | 0.98 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL1231246 | 0.98 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL22370200 | 0.98 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL22129258 | 0.98 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 | |
| Diclofenac SCHEMBL40785 | 0.98 | PTGS2 (0.97) | PTGS2CXCL8TTRPTGS1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117305402-A | Method and system for predicting drug-induced acute injury based on liver organoid model | 江苏运动健康研究院 | 2023-12-29 | — | — | CN | claimed |
| WO-2007110755-A1 | PROPHYLAXIS OR TREATMENT OF CARDIOVASCULAR INFLAMMATION | MEDICAL THERAPIES LIMITED (AU) | 2007-10-04 | — | — | WO | claimed |
| WO-2007109845-A1 | PROPHYLAXIS OR TREATMENT OF DIABETES | MEDICAL THERAPIES LIMITED (AU) | 2007-10-04 | — | — | WO | claimed |
| WO-2007026240-A1 | SUNSCREEN AND COSMETIC COMPOSITIONS FOR PROPHYLAXIS OR TREATMENT OF SKIN CANCERS | MEDICAL THERAPIES LIMITED (AU) | 2007-03-08 | — | — | WO | claimed |
| WO-2006099685-A1 | METHOD FOR THE PROPHYLAXIS OR TREATMENT OF CARCINOMAS | MEDICAL THERAPIES LIMITED (AU) | 2006-09-28 | — | — | WO | claimed |
| CN-117305402-A | Method and system for predicting drug-induced acute injury based on liver organoid model | 江苏运动健康研究院 | 2023-12-29 | — | — | CN | disclosed |
| CN-114746753-A | Correlating AKR1C3 enzyme expression level through prostaglandin content and screening administration application | 深圳艾欣达伟医药科技有限公司 | 2022-07-12 | — | — | CN | disclosed |
| CN-106109444-B | Thin layer and liquid combined transdermal drug delivery system | 张洁 | 2019-12-13 | — | — | CN | disclosed |
| CN-108570038-A | Dihydro-quinoxaline class bromine structural domain identifies protein inhibitor and preparation method and purposes | 中国科学院上海药物研究所 | 2018-09-25 | — | — | CN | disclosed |
| CN-108348894-A | Ozonolysis for compound activation and ozonolysis | 空气交叉股份有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-107793371-A | A kind of bromine domain identification protein inhibitor and its production and use | 中国科学院上海药物研究所 | 2018-03-13 | — | — | CN | disclosed |
| CN-107473536-A | A kind of water treatment system and method for three-dimensional class electricity Fenton degraded Diclofenac | 齐鲁理工学院 | 2017-12-15 | — | — | CN | disclosed |
| WO-2006099685-A1 | METHOD FOR THE PROPHYLAXIS OR TREATMENT OF CARCINOMAS | MEDICAL THERAPIES LIMITED (AU) | 2006-09-28 | — | — | WO | disclosed |
| WO-2005094809-A1 | A COMPOSITION CONTAINING A COMPLEX COMPRISING A METAL ION AND A CARBOXYLATE LIGAND HAVING ANTI-INFLAMMATORY ACTIVITY | MEDICAL THERAPIES LIMITED (AU) | 2005-10-13 | — | — | WO | disclosed |
| EP-0132690-B1 | THERMOPLASTICS CONTAINING ANTIPHLOGISTICS | Troponwerke GmbH & Co. KG (DE) | 1989-02-01 | — | — | EP | disclosed |
| US-4778799-A | ANALGESIC, ANTIPYRETIC, ANTIINFLAMMATORY AGENT | TIBES ULRICH (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0132690-A1 | Thermoplastics containing antiphlogistics | Troponwerke GmbH & Co. KG (DE) | 1985-02-13 | — | — | EP | disclosed |
| US-4292319-A | MIXTURE WITH AN ANTIULCER AGENT | BOEHRINGER INGELHEIM GMBH (DE) | 1981-09-29 | — | — | US | disclosed |
| US-4256747-A | ANTIINFLAMMATORY AGENTS, PYRIDO/2,3B//1,4/BENZODIAZEPIN-6-ONES | BOEHRINGER INGELHEIM GMBH (DE) | 1981-03-17 | — | — | US | disclosed |
| US-4154833-A | INDOMETHACIN (1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID) WITH PIRENZEPINE (5,11-DIHYDRO-11-((4-METHYL-1-PIPERAZINYL)-ACETYL)-6H-PYRIDO(2,3 -B)(1,4)BENZODIAZEPIN-6-ONE) | BOEHRINGER INGELHEIM GMBH (DE) | 1979-05-15 | — | — | US | disclosed |