Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.55 |
| ▸ | MMP13 | P45452 | 11/20 | 0.55 |
| ▸ | MMP2 | P08253 | 5/20 | 0.53 |
| ▸ | MMP9 | P14780 | 6/20 | 0.48 |
| ▸ | MMP1 | P03956 | 6/20 | 0.46 |
| ▸ | MMP14 | P50281 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949527 | 0.83 | ADAM17 (0.62) | ADAM17MMP13MMP2MMP9MMP1 | |
| SCHEMBL6267645 | 0.80 | ADAM17 (0.62) | ADAM17MMP13MMP2MMP9MMP1 | |
| SCHEMBL7394890 | 0.79 | ADAM17 (0.52) | ADAM17MMP13MMP2MMP9MMP1 | |
| SCHEMBL3948394 | 0.79 | ADAM17 (0.67) | ADAM17MMP13MMP2MMP9MMP1 | |
| SCHEMBL6658733 | 0.77 | ADAM17 (0.47) | ADAM17MMP13MMP2MMP9MMP1 | |
| SCHEMBL6268743 | 0.74 | ADAM17 (0.49) | ADAM17MMP13MMP2MMP9MMP1 | |
| SCHEMBL6694069 | 0.73 | ADAM17 (0.62) | ADAM17MMP13MMP2MMP9MMP1 | |
| SCHEMBL4151877 | 0.71 | ADAM17 (0.77) | ADAM17MMP13MMP9MMP1MMP14 | |
| SCHEMBL6268536 | 0.71 | ADAM17 (1.00) | ADAM17MMP13MMP2MMP9MMP1 | |
| Hydrochloric Acid SCHEMBL3947782 | 0.70 | ADAM17 (0.98) | ADAM17MMP13MMP2MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147085-B1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | WYETH CORP (US) | 2005-11-16 | — | — | EP | claimed |