Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.52 |
| ▸ | MMP13 | P45452 | 11/20 | 0.52 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | MMP1 | P03956 | 6/20 | 0.42 |
| ▸ | MMP14 | P50281 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949527 | 0.87 | ADAM17 (0.62) | ADAM17MMP13MMP2MMP1MMP14 | |
| SCHEMBL3949530 | 0.82 | ADAM17 (0.44) | ADAM17MMP13MMP2MMP1MMP14 | |
| SCHEMBL6263128 | 0.79 | ADAM17 (0.55) | ADAM17MMP13MMP2MMP1MMP14 | |
| SCHEMBL6694069 | 0.77 | ADAM17 (0.62) | ADAM17MMP13MMP2MMP1MMP14 | |
| SCHEMBL3948394 | 0.74 | ADAM17 (0.67) | ADAM17MMP13MMP2MMP1MMP14 | |
| SCHEMBL6658727 | 0.74 | ADAM17 (0.47) | ADAM17MMP13MMP2MMP1MMP14 | |
| SCHEMBL6266263 | 0.74 | ADAM17 (0.79) | ADAM17MMP13MMP2MMP1MMP14 | |
| SCHEMBL6658733 | 0.71 | ADAM17 (0.47) | ADAM17MMP13MMP2MMP1MMP14 | |
| SCHEMBL6657415 | 0.70 | ADAM17 (0.63) | ADAM17MMP13MMP1MMP14MMP9 | |
| SCHEMBL6661137 | 0.70 | ALDH1A1 (0.58) | ADAM17MMP13MMP2MMP1MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147085-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS / TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | American Cyanamid Company (US) | 2001-10-24 | — | — | EP | disclosed |
| WO-2000044723-A1 | ALKYNYL CONTAINING HYDROXAMIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS/TNF-ALPHA CONVERTING ENZYME (TACE) INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-08-03 | — | — | WO | disclosed |