Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 4/20 | 0.90 |
| ▸ | NPC1 | O15118 | 3/20 | 0.90 |
| ▸ | RAB9A | P51151 | 3/20 | 0.90 |
| ▸ | MEN1 | O00255 | 2/20 | 0.90 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.90 |
| ▸ | MAPT | P10636 | 2/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.90 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.90 |
| ▸ | PTPRC | P08575 | 7/20 | 0.69 |
| ▸ | PTPN13 | Q12923 | 3/20 | 0.69 |
| ▸ | CTSL | P07711 | 2/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.69 |
| ▸ | CTSS | P25774 | 2/20 | 0.69 |
| ▸ | LCK | P06239 | 1/20 | 0.69 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3954523 | 0.97 | MAOA (0.84) | MAOANPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL29539012 | 0.97 | MAOA (0.97) | MAOANPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL9261554 | 0.97 | MAOA (0.97) | MAOANPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL2812760 | 0.95 | MAOA (1.00) | MAOANPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL21840827 | 0.93 | MAOA (0.90) | MAOANPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL4291944 | 0.89 | MAOA (0.89) | MAOANPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL22321720 | 0.89 | MAOA (0.83) | MAOANPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL11475238 | 0.84 | MAOA (0.75) | MAOANPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL11481336 | 0.83 | MAPT (0.73) | MAOANPC1RAB9AMEN1ALDH1A1 | |
| SCHEMBL13165575 | 0.83 | ALDH1A1 (0.67) | MAOANPC1RAB9AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200155609-A1 | COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING PTEN INHIBITORS | TRANSFUSION HEALTH LLC | 2020-05-21 | — | — | US | disclosed |
| US-20200155609-A1 | COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING PTEN INHIBITORS | TRANSFUSION HEALTH LLC | 2020-05-21 | — | — | US | disclosed |
| EP-3630956-A1 | COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING PTEN INHIBITORS | Transfusion Health, LLC (US) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018217567-A1 | COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING PTEN INHIBITORS | TRANSFUSION HEALTH, LLC (US) | 2018-11-29 | — | — | WO | disclosed |
| EP-1242363-B1 | CD45 INHIBITORS | ASTRAZENECA AB (SE) | 2005-11-02 | — | — | EP | disclosed |
| US-20030207812-A1 | Cd45 inhibitors | ASTRAZENECA AB (SE) | 2003-11-06 | — | — | US | disclosed |
| EP-1242363-A2 | CD45 INHIBITORS | AstraZeneca AB (SE) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001046125-A2 | CD45 INHIBITORS | ASTRAZENECA AB (SE) | 2001-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207812-A1 | Cd45 inhibitors | CD74, CD2, PTPRC | MAOA 2792/4885NPC1 3699/4885RAB9A 1987/4885 |
| US-20200155609-A1 | COMPOSITIONS AND METHODS OF MAKING EXPANDED HEMATOPOIETIC STEM CELLS USING PTEN INHIBITORS | PTEN, MCL1, PIK3CA | MAOA 4479/4885NPC1 1762/4885RAB9A 799/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.