Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.79 |
| ▸ | TP53 | P04637 | 3/20 | 0.79 |
| ▸ | COMT | P21964 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | RECQL | P46063 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | ATM | Q13315 | 1/20 | 0.72 |
| ▸ | MMP2 | P08253 | 1/20 | 0.67 |
| ▸ | MMP9 | P14780 | 1/20 | 0.67 |
| ▸ | MMP8 | P22894 | 1/20 | 0.67 |
| ▸ | MMP13 | P45452 | 1/20 | 0.67 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.66 |
| ▸ | HPSE | Q9Y251 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6247649 | 0.89 | HPSE (0.82) | MAPTTP53COMTKMT2AMEN1 | |
| SCHEMBL17498727 | 0.86 | COMT (0.72) | MAPTTP53COMTKMT2AMEN1 | |
| SCHEMBL17498783 | 0.86 | COMT (0.72) | MAPTTP53COMTKMT2AMEN1 | |
| SCHEMBL12351257 | 0.85 | MAPT (0.80) | MAPTTP53COMTKMT2AMEN1 | |
| SCHEMBL14615299 | 0.85 | MAPT (0.66) | MAPTTP53KMT2AMEN1KDM4E | |
| SCHEMBL14615274 | 0.85 | MAPT (0.80) | MAPTTP53KMT2AMEN1KDM4E | |
| SCHEMBL25200815 | 0.84 | COMT (0.63) | MAPTTP53COMTKMT2AMEN1 | |
| SCHEMBL30443231 | 0.84 | COMT (0.63) | MAPTTP53COMTKMT2AMEN1 | |
| SCHEMBL2582594 | 0.84 | MAPT (1.00) | MAPTTP53COMTKMT2AMEN1 | |
| SCHEMBL31578829 | 0.84 | MAPT (1.00) | MAPTTP53COMTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030206-A1 | ARYL-1,3-AZOLE DERIVATIVES AND METHODS FOR INHIBITING HEPARNASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-04-07 | — | — | WO | disclosed |