Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.80 |
| ▸ | TP53 | P04637 | 4/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 3/20 | 0.64 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
| ▸ | SMO | Q99835 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14615276 | 0.90 | MAPT (0.76) | MAPTSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL30442877 | 0.85 | MAPT (0.63) | MAPTSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL25232982 | 0.85 | MAPT (0.63) | MAPTSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL6263969 | 0.85 | MAPT (0.79) | MAPTSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL14615293 | 0.83 | MAPT (0.72) | MAPTSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL14615299 | 0.83 | MAPT (0.66) | MAPTTP53ALDH1A1KMT2AMEN1 | |
| SCHEMBL13679553 | 0.82 | MAPT (0.71) | MAPTSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL13679550 | 0.82 | MAPT (0.70) | MAPTSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL14615292 | 0.80 | MAPT (0.69) | MAPTSMN1; SMN2TP53ALDH1A1KMT2A | |
| SCHEMBL6246003 | 0.80 | HPSE (0.80) | MAPTKMT2AMEN1KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354397-B2 | Controlling cell differentiation, cell proliferation; anticancer agents | CURIS, INC. (US) | 2013-01-15 | — | — | US | disclosed |