Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23836848 | 0.77 | HPGD (0.41) | SMN1; SMN2LMNA | |
| SCHEMBL923029 | 0.75 | — | — | |
| SCHEMBL28160881 | 0.73 | — | — | |
| SCHEMBL10138657 | 0.73 | — | — | |
| SCHEMBL18233007 | 0.72 | ALPL (0.42) | GAAKMT2ANPC1RAB9ALMNA | |
| Hydrochloric Acid SCHEMBL20476862 | 0.71 | — | — | |
| SCHEMBL13827683 | 0.71 | HTT (0.42) | GAASMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL628228 | 0.70 | — | — | |
| SCHEMBL921991 | 0.70 | — | — | |
| SCHEMBL13827584 | 0.70 | TRPM8 (0.36) | GAACYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012154880-A1 | PROTEOSTASIS REGULATORS FOR TREATING CYSTIC FIBROSIS AND OTHER PROTEIN MISFOLDING DISEASES | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2012-11-15 | — | — | WO | disclosed |
| WO-2012019954-A1 | PYRAZOLOPYRIDINE COMPOUNDS AS PDE10A INHIBITORS | EVOTEC (UK) LTD. (GB) | 2012-02-16 | — | — | WO | disclosed |