Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29994976 | 0.73 | MYC (0.51) | ALDH1A1LMNATSHRHSD17B10POLB | |
| SCHEMBL28343653 | 0.73 | KDM4E (0.60) | ALDH1A1LMNASIRT1HIF1ATSHR | |
| SCHEMBL10210904 | 0.71 | KDM4E (0.63) | ALDH1A1LMNASIRT1HIF1AHSD17B10 | |
| Hydrochloric Acid SCHEMBL6580775 | 0.71 | KDM4E (0.59) | ALDH1A1LMNASIRT1HIF1ATSHR | |
| SCHEMBL6585398 | 0.70 | HDAC3 (0.56) | ALDH1A1LMNASIRT1KMT2AKDM4E | |
| SCHEMBL7649030 | 0.70 | KDM4E (0.49) | ALDH1A1LMNATSHRPOLBKMT2A | |
| SCHEMBL70322 | 0.70 | ALDH1A1 (0.66) | ALDH1A1LMNAHIF1ATSHRHSD17B10 | |
| SCHEMBL10360804 | 0.70 | ALDH1A1 (0.77) | ALDH1A1LMNAHIF1ATSHRHSD17B10 | |
| SCHEMBL156281 | 0.70 | ALDH1A1 (0.66) | ALDH1A1LMNAHIF1ATSHRHSD17B10 | |
| SCHEMBL417711 | 0.70 | ALDH1A1 (0.60) | ALDH1A1LMNAHIF1ATSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465869-A4 | MODULATORS OF LXR | X CEPTOR THERAPEUTICS INC (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1465869-A1 | MODULATORS OF LXR | X-Ceptor Therapeutics, Inc. (US) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003059884-A1 | MODULATORS OF LXR | X-CEPTOR THERAPEUTICS, INC. (US) | 2003-07-24 | — | — | WO | disclosed |