Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.50 |
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | RXRB | P28702 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6261737 | 0.87 | MAOB (0.55) | NPC1RAB9ASMN1; SMN2MAOBKDM4E | |
| SCHEMBL5926172 | 0.86 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MAOBKDM4E | |
| SCHEMBL4677286 | 0.85 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2MAOBKDM4E | |
| SCHEMBL5383914 | 0.83 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2MAOBKDM4E | |
| SCHEMBL28784720 | 0.82 | KCNN4 (0.58) | MEN1MAPTKMT2AALDH1A1HDAC3 | |
| SCHEMBL17978729 | 0.81 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2MAOBKDM4E | |
| SCHEMBL4179965 | 0.79 | PPARG (0.64) | NPC1RAB9ASMN1; SMN2MAOBKDM4E | |
| SCHEMBL6739376 | 0.79 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2MAOBKDM4E | |
| SCHEMBL6266539 | 0.78 | ADAM17 (0.57) | SMN1; SMN2 | |
| SCHEMBL28894766 | 0.78 | CTRC (0.52) | MAOBKDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005085232-A1 | HYDANTOIN DERIVATIVES FOR USE AS TACE AND AGGRECANASE INHIBITORS | ASTRAZENECA AB (SE) | 2005-09-15 | — | — | WO | disclosed |