Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.52 |
| ▸ | PTPRF | P10586 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 4/20 | 0.48 |
| ▸ | CHUK | O15111 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3910841 | 0.87 | PTPN1 (0.53) | PTPN1PTPRFIKBKBCYP1A2CYP3A4 | |
| SCHEMBL3911638 | 0.83 | PTPRF (0.53) | PTPN1PTPRFPTGDR2PPARD | |
| SCHEMBL3916115 | 0.77 | IKBKB (0.57) | PTPN1PKMIKBKBCYP1A2CYP3A4 | |
| SCHEMBL17226334 | 0.75 | PTPN1 (0.56) | PTPN1IKBKBCHUKCYP1A2CYP3A4 | |
| SCHEMBL2313705 | 0.74 | IKBKB (0.77) | PTPN1PKMIKBKBCHUKCYP1A2 | |
| SCHEMBL3601307 | 0.74 | PTPN1 (0.58) | PTPN1PTPRFIKBKBCHUKCYP1A2 | |
| SCHEMBL3906261 | 0.74 | HPGD (0.47) | PTPN1PTPRFPTGDR2KDM4ESMN1; SMN2 | |
| SCHEMBL11625356 | 0.72 | TDP1 (0.47) | PTPN1PTPRFCYP2C19PTGDR2PTGDR | |
| SCHEMBL9826543 | 0.72 | MAPT (0.56) | PTPN1PTPRFPKMIKBKBCYP1A2 | |
| SCHEMBL6348871 | 0.72 | PTPN1 (0.56) | PTPN1PTPRFIKBKBCHUKCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592421-A1 | HETEROARYLALKANOIC ACIDS AS INTEGRIN RECEPTOR ANTAGONISTS | Pharmacia Corporation (US) | 2005-11-09 | — | — | EP | claimed |
| WO-2004058254-A1 | HETEROARYLALKANOIC ACIDS AS INTEGRIN RECEPTOR ANTAGONISTS | PHARMACIA CORPORATION (US) | 2004-07-15 | — | — | WO | claimed |
| WO-2005081954-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |