Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 8/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.77 |
| ▸ | CHUK | O15111 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 9/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.63 |
| ▸ | RAB9A | P51151 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | BTK | Q06187 | 1/20 | 0.57 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.56 |
| ▸ | TUBB | P07437 | 1/20 | 0.56 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.56 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.56 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.56 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.56 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4091841 | 0.87 | IKBKB (1.00) | IKBKBCYP1A2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL29906389 | 0.86 | IKBKB (0.60) | IKBKBCYP1A2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL875389 | 0.86 | IKBKB (0.60) | IKBKBCYP1A2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL2044907 | 0.84 | IKBKB (0.77) | IKBKBCYP1A2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL5192759 | 0.84 | IKBKB (0.55) | IKBKBCYP1A2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL15881509 | 0.83 | MAPT (0.59) | IKBKBCYP1A2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL3081896 | 0.83 | MAPT (0.63) | IKBKBCYP1A2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL1144476 | 0.83 | IKBKB (0.77) | IKBKBCYP1A2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL2158576 | 0.83 | IKBKB (0.75) | IKBKBCYP1A2CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL7809672 | 0.83 | IKBKB (0.54) | IKBKBCYP1A2CYP2C9CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1876179-B1 | Thienopyrimidone compounds | TAKEDA PHARMACEUTICAL (JP) | 2015-03-25 | — | — | EP | disclosed |
| WO-2014111666-A1 | THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE DERIVATIVES AND THE PREPARATION AND PHARMACEUTICAL USES THEREOF | UNIVERSITE D'AIX-MARSEILLE (FR) | 2014-07-24 | — | — | WO | disclosed |
| US-7989445-B2 | Thienopyrimidone compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |
| US-20100069362-A1 | Thienopyrimidone compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-18 | — | — | US | disclosed |
| EP-1597247-B1 | SUBSTITUTED 3-(BENZOYLUREIDO)-THIOPHENE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-07-23 | — | — | EP | disclosed |
| EP-1876179-A1 | THIENOPYRIMIDONE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-01-09 | — | — | EP | disclosed |
| CN-101098852-A | Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof | SMITHKLINE BEECHAM CORP (US) | 2008-01-02 | — | — | CN | disclosed |
| US-20070249670-A1 | Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof | SMITHKLINE BEECHAM CORPORATION (US) | 2007-10-25 | — | — | US | disclosed |
| EP-1812383-A1 | GLYCOGEN PHOSPHORYLASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | Smithkline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| US-7196114-B2 | Substituted 3-(benzoylureido) thiophene derivatives, processes for preparing them and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-03-27 | — | — | US | disclosed |
| CN-1751036-A | Substituted 3-(benzoylureido)-thiophene derivatives, method for the production and use thereof | AVENTIS PHARMA GMBH (DE) | 2006-03-22 | — | — | CN | disclosed |
| EP-1597247-A1 | SUBSTITUTED 3-(BENZOYLUREIDO)-THIOPHENE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF | Sanofi-Aventis Deutschland GmbH (DE) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004092181-A9 | HETEROCYCLIC MCHR1 ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-01-27 | — | — | WO | disclosed |
| US-20040198742-A1 | Substituted 3-(benzoylureido) thiophene derivatives, processes for preparing them and their use | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-10-07 | — | — | US | disclosed |
| WO-2004072060-A1 | SUBSTITUTED 3-(BENZOYLUREIDO)-THIOPHENE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-08-26 | — | — | WO | disclosed |
| EP-0783501-B9 | PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY | URIACH & CIA SA J (ES) | 2001-07-25 | — | — | EP | disclosed |
| EP-0783501-B1 | PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY | URIACH & CIA SA J (ES) | 2001-01-10 | — | — | EP | disclosed |
| US-5807854-A | THERAPY FOR FUNGI INFECTIONS IN PLANTS, ANIMALS | J. URIAH & CIA. S.A. (ES) | 1998-09-15 | — | — | US | disclosed |
| EP-0783501-A1 | NEW PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY | J. URIACH & CIA. S.A. (ES) | 1997-07-16 | — | — | EP | disclosed |
| WO-1997005130-A1 | NEW PYRIMIDONE DERIVATIVES WITH ANTIFUNGAL ACTIVITY | J. URIACH & CIA. S.A. (ES) | 1997-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249670-A1 | Glycogen Phosphorylase Inhibitor Compounds and Pharmaceutical Compositions Thereof | PYGM, PYGL, GYS1 | IKBKB 792/4885CYP1A2 3345/4885CYP2C9 2982/4885 |
| US-20100069362-A1 | Thienopyrimidone compound | MC1R, MC2R, MC5R | IKBKB 3035/4885CYP1A2 579/4885CYP2C9 1104/4885 |
| US-20040198742-A1 | Substituted 3-(benzoylureido) thiophene derivatives, processes for preparing them and their use | SLC5A2, TXNRD2, SLC5A1 | IKBKB 1750/4885CYP1A2 26/4885CYP2C9 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.