Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 14/20 | 0.62 |
| ▸ | PGR | P06401 | 11/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702715 | 0.83 | PGR (0.74) | NR3C1PGRALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL4182720 | 0.81 | PGR (0.68) | NR3C1PGRALDH1A1HPGD | |
| SCHEMBL4702989 | 0.81 | NR3C1 (0.77) | NR3C1PGR | |
| SCHEMBL4184364 | 0.80 | PGR (0.63) | NR3C1PGR | |
| SCHEMBL4704933 | 0.80 | NR3C1 (0.79) | NR3C1PGR | |
| SCHEMBL4702879 | 0.78 | NR3C1 (0.76) | NR3C1PGR | |
| SCHEMBL4702557 | 0.77 | NR3C1 (1.00) | NR3C1PGR | |
| SCHEMBL4702588 | 0.77 | NR3C1 (0.74) | NR3C1PGR | |
| SCHEMBL27492596 | 0.76 | PGR (0.65) | NR3C1PGR | |
| SCHEMBL4705696 | 0.75 | NR3C1 (0.81) | NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532113-A2 | SUBSTITUTED HIHYDROQUINOLINES AS GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004018429-A2 | SUBSTITUTED HIHYDROQUINOLINES AS GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2004-03-04 | — | — | WO | disclosed |