Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 5/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.74 |
| ▸ | RAB9A | P51151 | 3/20 | 0.74 |
| ▸ | TP53 | P04637 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.74 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | MMP2 | P08253 | 5/20 | 0.68 |
| ▸ | MMP9 | P14780 | 5/20 | 0.68 |
| ▸ | MMP8 | P22894 | 5/20 | 0.68 |
| ▸ | MMP13 | P45452 | 5/20 | 0.68 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.66 |
| ▸ | MGAM | O43451 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | SI | P14410 | 3/20 | 0.59 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13963958 | 0.92 | HPSE (0.74) | HPSEKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL8768923 | 0.90 | HPSE (0.71) | HPSEKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL6529350 | 0.86 | HPSE (1.00) | HPSEKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL13405867 | 0.85 | KDM4E (1.00) | HPSEKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL6585826 | 0.83 | HPSE (0.67) | HPSEKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL2242293 | 0.81 | MMP2 (1.00) | HPSEKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL7945641 | 0.81 | MGAM (0.69) | HPSEKDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL11703118 | 0.80 | MAOB (0.71) | HPSEKDM4ENPC1RAB9ATP53 | |
| SCHEMBL6244081 | 0.80 | PRMT5 (1.00) | HPSENPC1RAB9AMMP2MMP9 | |
| SCHEMBL30615069 | 0.79 | MGAM (0.76) | HPSEKDM4EALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030206-A1 | ARYL-1,3-AZOLE DERIVATIVES AND METHODS FOR INHIBITING HEPARNASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-04-07 | — | — | WO | disclosed |