Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8430194 | 0.82 | TERT (0.40) | KDM4ERAB9APOLBLMNAALDH1A1 | |
| SCHEMBL382590 | 0.81 | KDM4E (0.48) | KDM4ERAB9APOLBLMNAALDH1A1 | |
| SCHEMBL94397 | 0.81 | POLB (0.52) | KDM4ERAB9APOLBLMNAALDH1A1 | |
| Trifluoromethanesulfonic Acid SCHEMBL3855070 | 0.81 | KCNH2 (0.43) | ATMACHEKCNH2 | |
| Anthracene SCHEMBL31707343 | 0.81 | TUBB4A (0.45) | LMNASMN1; SMN2RAD52ACHEHTR1A | |
| SCHEMBL278568 | 0.80 | ATM (0.56) | KDM4ERAB9APOLBLMNAATM | |
| SCHEMBL29464772 | 0.80 | ATM (0.56) | KDM4ERAB9APOLBLMNAATM | |
| SCHEMBL3396649 | 0.78 | KDM4E (0.41) | KDM4ELMNAALDH1A1ATMHPGD | |
| Bromide SCHEMBL11593076 | 0.78 | ATM (0.54) | KDM4ERAB9APOLBLMNAATM | |
| Iodide SCHEMBL11862696 | 0.78 | ATM (0.54) | KDM4ERAB9APOLBLMNAATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1141729-B1 | OPTICAL-CHEMICAL SENSOR FOR DETECTING CHLORIDE | HOFFMANN LA ROCHE (CH) | 2005-11-23 | — | — | EP | claimed |
| US-6835351-B2 | Linear chain hydrophile polymer carrying a luminescence indicator of a non-lipophile (bis)acridine compound; determination of the concentration of chloride | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-28 | — | — | US | claimed |
| US-20030101803-A1 | Optical-chemical sensor | F. HOFFMAN-LA ROCHE AG | 2003-06-05 | — | — | US | claimed |
| US-20020034826-A1 | Determination of chloride concentration in an aqueous sample by luminescence optics; indicator is non-lipophile acridine or bisacridine compound and polymer, a linear-chain hydrophile polymer soluble in an organic solvent | F. HOFFMAN-LA ROCHE AG | 2002-03-21 | — | — | US | claimed |
| EP-1141729-B1 | OPTICAL-CHEMICAL SENSOR FOR DETECTING CHLORIDE | HOFFMANN LA ROCHE (CH) | 2005-11-23 | — | — | EP | disclosed |
| US-6835351-B2 | Linear chain hydrophile polymer carrying a luminescence indicator of a non-lipophile (bis)acridine compound; determination of the concentration of chloride | F. HOFFMANN-LA ROCHE AG (CH) | 2004-12-28 | — | — | US | disclosed |
| US-6613282-B2 | Determination of chloride concentration in an aqueous sample by luminescence optics; indicator is non-lipophile acridine or bisacridine compound and polymer, a linear-chain hydrophile polymer soluble in an organic solvent | F. HOFFMAN-LA ROCHE AG (CH) | 2003-09-02 | — | — | US | disclosed |
| US-20030101803-A1 | Optical-chemical sensor | F. HOFFMAN-LA ROCHE AG | 2003-06-05 | — | — | US | disclosed |
| US-20020034826-A1 | Determination of chloride concentration in an aqueous sample by luminescence optics; indicator is non-lipophile acridine or bisacridine compound and polymer, a linear-chain hydrophile polymer soluble in an organic solvent | F. HOFFMAN-LA ROCHE AG | 2002-03-21 | — | — | US | disclosed |
| EP-1141729-A1 | OPTICAL-CHEMICAL SENSOR FOR DETECTING CHLORIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000042438-A1 | OPTICAL-CHEMICAL SENSOR FOR DETECTING CHLORIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2000-07-20 | — | — | WO | disclosed |