Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.82 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.82 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.82 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.82 |
| ▸ | STAT3 | P40763 | 2/20 | 0.82 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.82 |
| ▸ | RELA | Q04206 | 2/20 | 0.82 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.82 |
| ▸ | APP | P05067 | 3/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | CA12 | O43570 | 2/20 | 0.70 |
| ▸ | CA1 | P00915 | 2/20 | 0.70 |
| ▸ | CA2 | P00918 | 2/20 | 0.70 |
| ▸ | CA3 | P07451 | 2/20 | 0.70 |
| ▸ | PKM | P14618 | 2/20 | 0.70 |
| ▸ | CA4 | P22748 | 2/20 | 0.70 |
| ▸ | CA6 | P23280 | 2/20 | 0.70 |
| ▸ | CA5A | P35218 | 2/20 | 0.70 |
| ▸ | SNCA | P37840 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL626598 | 1.00 | CYP2D6 (0.82) | CYP2D6CYP1A2ALOX5NFKB1HSD11B1 | |
| SCHEMBL29478095 | 0.91 | CYP2D6 (1.00) | CYP2D6CYP1A2ALOX5NFKB1HSD11B1 | |
| SCHEMBL30668505 | 0.91 | CYP2D6 (1.00) | CYP2D6CYP1A2ALOX5NFKB1HSD11B1 | |
| SCHEMBL1493283 | 0.91 | CYP2D6 (1.00) | CYP2D6CYP1A2ALOX5NFKB1HSD11B1 | |
| SCHEMBL1493282 | 0.91 | CYP2D6 (1.00) | CYP2D6CYP1A2ALOX5NFKB1HSD11B1 | |
| SCHEMBL3337939 | 0.88 | CYP1A2 (0.63) | CYP2D6CYP1A2ALOX5NFKB1HSD11B1 | |
| SCHEMBL3337937 | 0.88 | CYP1A2 (0.63) | CYP2D6CYP1A2ALOX5NFKB1HSD11B1 | |
| SCHEMBL29428460 | 0.88 | KDM4E (0.69) | CYP2D6CYP1A2ALOX5NFKB1HSD11B1 | |
| SCHEMBL2744234 | 0.86 | CYP2D6 (0.91) | CYP2D6CYP1A2ALOX5NFKB1HSD11B1 | |
| SCHEMBL2744233 | 0.86 | CYP2D6 (0.91) | CYP2D6CYP1A2ALOX5NFKB1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054365-A2 | METHODS TO PREPARE PENTA-1,4-DIEN-3-ONES AND SUBSTITUTED CYCLOHEXANONES AND DERIVATIVES WITH ANTITUMORAL AND ANTIPARASITIC PROPERTIES, THE COMPOUNDS AND THEIR USES | Uniban - Universidade Bandeirante De São Paulo (BR) | 2009-05-06 | — | — | EP | claimed |
| WO-2008003155-A2 | METHODS TO PREPARE PENTA-1,4-DIEN-3-ONES AND SUBSTITUTED CYCLOHEXANONES AND DERIVATIVES WITH ANTITUMORAL AND ANTIPARASITIC PROPERTIES, THE COMPOUNDS AND THEIR USES | UNIBAN - UNIVERSIDADE BANDEIRANTE DE SÃO PAULO - ACADEMIA PAULISTA ANCHIETA S/C LTDA (BR) | 2008-01-10 | — | — | WO | claimed |
| CN-114478256-A | Preparation method of novel curcumin derivative and application of novel curcumin derivative in resisting liver cancer | 安徽理工大学环境友好材料与职业健康研究院(芜湖) | 2022-05-13 | — | — | CN | disclosed |
| EP-2441452-A1 | PHARMACEUTICAL COMPOSITION AND USE OF THE PHARMACEUTICAL COMPOSITION FOR THE TREATMENT, PROPHYLAXIS OR PREVENTION OF NEOPLASTIC DISEASES IN HUMANS AND ANIMALS | Universidade Bandeirante De São Paulo - Academia Paulista Anchieta S/C Ltda (BR) | 2012-04-18 | — | — | EP | disclosed |
| US-20120082703-A1 | PHARMACEUTICAL COMPOSITION AND USE OF THE PHARMACEUTICAL COMPOSITION FOR THE TREATMENT, PROPHYLAXIS OR PREVENTION OF NEOPLASTIC DISEASES IN HUMANS AND ANIMALS | UNIVERSIDADE BANDEIRANTE DE SAO PAULO-ACADEMIA PAULISTA ANCHETA S/C LTDA (BR) | 2012-04-05 | — | — | US | disclosed |
| WO-2012021692-A1 | CURCUMIN ANALOGS AND METHODS OF USE THEREOF | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-02-16 | — | — | WO | disclosed |
| EP-2054365-A2 | METHODS TO PREPARE PENTA-1,4-DIEN-3-ONES AND SUBSTITUTED CYCLOHEXANONES AND DERIVATIVES WITH ANTITUMORAL AND ANTIPARASITIC PROPERTIES, THE COMPOUNDS AND THEIR USES | Uniban - Universidade Bandeirante De São Paulo (BR) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008003155-A2 | METHODS TO PREPARE PENTA-1,4-DIEN-3-ONES AND SUBSTITUTED CYCLOHEXANONES AND DERIVATIVES WITH ANTITUMORAL AND ANTIPARASITIC PROPERTIES, THE COMPOUNDS AND THEIR USES | UNIBAN - UNIVERSIDADE BANDEIRANTE DE SÃO PAULO - ACADEMIA PAULISTA ANCHIETA S/C LTDA (BR) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120082703-A1 | PHARMACEUTICAL COMPOSITION AND USE OF THE PHARMACEUTICAL COMPOSITION FOR THE TREATMENT, PROPHYLAXIS OR PREVENTION OF NEOPLASTIC DISEASES IN HUMANS AND ANIMALS | BRCA1, TSG101, POLN | CYP2D6 1087/4885CYP1A2 1246/4885ALOX5 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.