Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.53 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.53 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | LTK | P29376 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | CDK7 | P50613 | 1/20 | 0.53 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.53 |
| ▸ | MST1R | Q04912 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.53 |
| ▸ | SYK | P43405 | 12/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8411247 | 0.78 | MAPK1 (0.70) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8411239 | 0.78 | MAPK1 (0.70) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL7780481 | 0.76 | NTRK1 (0.83) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8431563 | 0.75 | NTRK1 (0.65) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8431566 | 0.75 | NTRK1 (0.65) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL5203073 | 0.74 | NTRK1 (0.75) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL25194772 | 0.72 | RPLP1 (0.49) | — | |
| SCHEMBL5201825 | 0.72 | NTRK1 (0.75) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8697609 | 0.72 | NTRK1 (0.75) | NTRK1NTRK3NTRK2PRKD3ABL1 | |
| SCHEMBL8583224 | 0.71 | SYK (0.82) | NTRK1NTRK3NTRK2PRKD3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005044181-A2 | PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2005-05-19 | — | — | WO | claimed |
| WO-2005044181-A2 | PROTECTION OF TISSUES AND CELLS FROM CYTOTOXIC EFFECTS OF IONIZING RADIATION BY ABL INHIBITORS | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2005-05-19 | — | — | WO | disclosed |