Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | PAK1 | Q13153 | 6/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.52 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | LTK | P29376 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | CDK7 | P50613 | 1/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.52 |
| ▸ | MST1R | Q04912 | 1/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8411247 | 1.00 | MAPK1 (0.70) | MAPK1PAK1NTRK1NTRK3NTRK2 | |
| SCHEMBL8429168 | 0.88 | PAK1 (0.68) | MAPK1PAK1NTRK1NTRK3NTRK2 | |
| SCHEMBL8429175 | 0.88 | PAK1 (0.68) | MAPK1PAK1NTRK1NTRK3NTRK2 | |
| SCHEMBL29537607 | 0.82 | MAPK1 (1.00) | MAPK1PAK1NTRK1NTRK3NTRK2 | |
| SCHEMBL8428761 | 0.82 | MAPK1 (1.00) | MAPK1PAK1NTRK1NTRK3NTRK2 | |
| SCHEMBL29355210 | 0.82 | MAPK1 (1.00) | MAPK1PAK1NTRK1NTRK3NTRK2 | |
| SCHEMBL6266403 | 0.82 | MAPK1 (1.00) | MAPK1PAK1NTRK1NTRK3NTRK2 | |
| SCHEMBL5373331 | 0.78 | TLK2 (0.67) | NTRK1PDGFRBFLT3AURKBKDR | |
| SCHEMBL6266401 | 0.78 | NTRK1 (0.53) | MAPK1NTRK1NTRK3NTRK2PDGFRB | |
| SCHEMBL7555701 | 0.77 | MAPK1 (0.65) | MAPK1PAK1NTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752985-B1 | HYDROSOLUBLE 3-ARYLIDENE-2-OXINDOLE DERIVATIVES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 1999-08-04 | — | — | EP | claimed |