L-Homocysteine

L-Homocysteine

SCHEMBL6266569

CC(=O)c1ccccc1C(=O)O.N[C@@H](CCS)C(=O)O

nearest known ligand 0.52

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALPI P09923 1/20 0.45
PKM P14618 1/20 0.45
PTGS1 P23219 1/20 0.45
XIAP P98170 1/20 0.45
SLC7A5 Q01650 1/20 0.45
FOLH1 Q04609 3/20 0.43
KIF11 P52732 7/20 0.43
ALDH1A1 P00352 1/20 0.42
ALOX15 P16050 1/20 0.42
MAPT P10636 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
FNTA P49354 1/20 0.39
FNTB P49356 1/20 0.39
LTA4H P09960 1/20 0.38
POLB P06746 1/20 0.38
KMT2A Q03164 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
NOS3 P29474 1/20 0.38
NOS1 P29475 1/20 0.38
NOS2 P35228 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Homocysteine SCHEMBL8642355 1.00 ALPI (0.45) ALPIPKMPTGS1XIAPSLC7A5
Cysteine SCHEMBL8640370 0.88 PTGS1 (0.52) ALPIPKMPTGS1XIAPSLC7A5
Cysteine SCHEMBL8640367 0.88 PTGS1 (0.52) ALPIPKMPTGS1XIAPSLC7A5
Phenylalanine SCHEMBL27523453 0.78 SLC7A5 (0.76) ALPIPKMPTGS1XIAPSLC7A5
Dl-Phenylalanine SCHEMBL27523454 0.78 SLC7A5 (0.76) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL286653 0.76 ALDH1A1 (0.74) PTGS1ALDH1A1ALOX15MAPTHDAC8
Benzene SCHEMBL11756425 0.76 ALDH1A1 (0.74) PTGS1ALDH1A1ALOX15MAPTHDAC8
Phthalic Acid SCHEMBL8407913 0.76 CYP1A2 (0.64) ALPIPKMPTGS1XIAPSLC7A5
Phthalic Acid SCHEMBL8407915 0.76 CYP1A2 (0.64) ALPIPKMPTGS1XIAPSLC7A5
SCHEMBL29151570 0.74 KDM4E (0.58) ALPIPKMPTGS1XIAPSLC7A5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1224467-B1 PROTECTING ALKYLATING REAGENTS USED FOR QUANTIFYING HOMOCYSTEINE DADE BEHRING MARBURG GMBH (DE) 2005-11-30 EP disclosed
US-20040198703-A1 Protecting groups for biological labeling KECZER STEYE DE (US) 2004-10-07 US disclosed
US-6783947-B1 FOR DETECTING AMOUNT OF HOMOCYSTEINE IN SAMPLE; COMPRISES ALPHA-HALOKETONE AND DEPROTECTING AGENTS; FOR BIOASSAYS/CONJUGATION KITS DADE BEHRING MARBURG GMBH (DE) 2004-08-31 US disclosed
EP-1224467-A2 PROTECTING ALKYLATING REAGENTS USED FOR QUANTIFYING HOMOCYSTEINE Dade Behring Marburg GmbH (DE) 2002-07-24 EP disclosed
WO-2001018548-A2 PROTECTING ALKYLATING REAGENTS USED FOR QUANTIFYING HOMOCYSTEINE DADE BEHRING MARBURG GMBH (DE) 2001-03-15 WO disclosed
EP-0757794-B1 IMMUNOASSAY FOR HOMOCYSTEINE BEHRINGWERKE AG (DE) 1998-08-19 EP disclosed
US-5478729-A Immunoassay for homocysteine SYNTEX (U.S.A.) INC. (US) 1995-12-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040198703-A1 Protecting groups for biological labeling MGMT, PTMS, BCKDK ALPI 2654/4885PKM 1377/4885PTGS1 3384/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.