Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HPD | P32754 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | PGR | P06401 | 2/20 | 0.43 |
| ▸ | RORA | P35398 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | RORB | Q92753 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10145941 | 0.83 | GRM2 (0.47) | GRM2TSHRALDH1A1HPDMAPK14 | |
| SCHEMBL27369455 | 0.81 | TSHR (0.57) | TSHRALDH1A1PGRRORARORC | |
| SCHEMBL625814 | 0.80 | GRM2 (1.00) | GRM2BRD4MAOB | |
| SCHEMBL14992269 | 0.80 | GRM2 (0.44) | GRM2HPDMAPK14PGR | |
| SCHEMBL10145952 | 0.78 | GRM2 (0.45) | GRM2KDM4EMAPK14RORARORC | |
| SCHEMBL10146323 | 0.78 | GRM2 (0.95) | GRM2BRD4 | |
| SCHEMBL10146576 | 0.78 | GRM2 (0.64) | GRM2BRD4MAOBMAPK14 | |
| SCHEMBL13304800 | 0.77 | TSHR (0.51) | TSHRALDH1A1HPGDPGRRORA | |
| SCHEMBL10146635 | 0.77 | GRM2 (0.62) | GRM2BRD4MAOBMAPK14 | |
| SCHEMBL22700961 | 0.77 | GRM2 (0.51) | GRM2BRD4MAOBMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603079-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-06-19 | — | — | EP | claimed |
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | claimed |