Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | ICMT | O60725 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | CDC25A | P30304 | 1/20 | 0.38 |
| ▸ | RORA | P35398 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | RORB | Q92753 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10145941 | 0.95 | GRM2 (0.47) | GRM2METAP2NPC1MAPK14RORA | |
| SCHEMBL10145948 | 0.90 | GRM2 (0.49) | GRM2METAP2MAPK14 | |
| SCHEMBL14992820 | 0.83 | PGR (0.44) | GRM2TMEM97SIGMAR1RORARORC | |
| SCHEMBL10146676 | 0.81 | GRM2 (0.47) | GRM2METAP2MAPK14 | |
| SCHEMBL10146668 | 0.81 | GRM2 (0.70) | GRM2METAP2 | |
| SCHEMBL10145950 | 0.80 | MAPK14 (0.53) | GRM2METAP2MAPK14KDM4EMAPT | |
| SCHEMBL626748 | 0.78 | GRM2 (0.67) | GRM2MAPK14KDM4ERORARORC | |
| SCHEMBL10146671 | 0.78 | PARG (0.51) | GRM2METAP2MAPK14 | |
| SCHEMBL10146004 | 0.78 | BRD4 (0.48) | GRM2HDAC1NPC1KDM4EMAPT | |
| SCHEMBL14992269 | 0.78 | GRM2 (0.44) | GRM2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |