Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.43 |
| ▸ | HPD | P32754 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 4/20 | 0.39 |
| ▸ | RORA | P35398 | 4/20 | 0.39 |
| ▸ | RORC | P51449 | 4/20 | 0.39 |
| ▸ | RORB | Q92753 | 4/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10145952 | 0.95 | GRM2 (0.45) | GRM2METAP2MAPK14RORARORC | |
| SCHEMBL10145948 | 0.92 | GRM2 (0.49) | GRM2METAP2HPDMAPK14CHEK1 | |
| SCHEMBL626748 | 0.83 | GRM2 (0.67) | GRM2HPDMAPK14PGRRORA | |
| SCHEMBL10146668 | 0.82 | GRM2 (0.70) | GRM2METAP2 | |
| SCHEMBL10146676 | 0.82 | GRM2 (0.47) | GRM2METAP2HPDMAPK14CHEK1 | |
| SCHEMBL10145950 | 0.82 | MAPK14 (0.53) | GRM2METAP2MAPK14CHEK1ALDH1A1 | |
| SCHEMBL14992269 | 0.82 | GRM2 (0.44) | GRM2HPDMAPK14PGR | |
| SCHEMBL10146004 | 0.80 | BRD4 (0.48) | GRM2HPDMEN1KMT2ANPC1 | |
| SCHEMBL10146671 | 0.80 | PARG (0.51) | GRM2METAP2MAPK14CHEK1 | |
| SCHEMBL14992820 | 0.78 | PGR (0.44) | GRM2PGRRORARORCRORB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012021382-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2012-02-16 | — | — | WO | disclosed |