Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 17/20 | 0.52 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MAST3 | O60307 | 4/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1934008 | 0.93 | HTR2C (0.46) | MAPK8HTR2C | |
| SCHEMBL6280533 | 0.79 | MAPK8 (0.50) | MAPK8 | |
| SCHEMBL6263352 | 0.78 | MAPK8 (0.49) | MAPK8 | |
| SCHEMBL6264246 | 0.76 | AURKA (0.60) | MAPK8 | |
| SCHEMBL6265223 | 0.76 | PIK3CA (0.53) | MAPK8 | |
| SCHEMBL6262205 | 0.76 | MAPK8 (0.47) | MAPK8MAST3MAPK9 | |
| SCHEMBL6261165 | 0.75 | MAPK8 (0.46) | MAPK8 | |
| SCHEMBL6264925 | 0.75 | MAPK8 (0.57) | MAPK8MAST3MAPK9 | |
| SCHEMBL6264959 | 0.75 | MAPK8 (0.46) | MAPK8MAPK9 | |
| SCHEMBL6270503 | 0.75 | AURKA (0.57) | MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005085252-A1 | IMIDAZO ‘1,2-A’ PYRAZINE COMPOUNDS WHICH INTERACT WITH PROTEIN KINASES | BIOFOCUS DISCOVERY LIMITED (GB) | 2005-09-15 | — | — | WO | disclosed |