Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6269604 | 1.00 | TRPV1 (0.42) | TRPV1MAPTPGRHTR1AADORA3 | |
| SCHEMBL6273056 | 0.89 | MEN1 (0.50) | TRPV1MAPTALOX5MEN1KMT2A | |
| SCHEMBL6271863 | 0.82 | ALOX5 (0.61) | MAPTPGRHTR1AADORA3PTGS1 | |
| SCHEMBL6271590 | 0.82 | ALOX5 (0.61) | MAPTPGRHTR1AADORA3PTGS1 | |
| SCHEMBL6273404 | 0.81 | TRPV1 (0.42) | TRPV1MAPTMEN1KMT2ACNR2 | |
| SCHEMBL6273624 | 0.81 | TRPV1 (0.42) | TRPV1MAPTMEN1KMT2ACNR2 | |
| SCHEMBL31576820 | 0.73 | CYP3A4 (0.52) | MAPTALOX5MEN1KMT2AKDM4E | |
| SCHEMBL26468487 | 0.72 | ALOX5 (0.55) | MAPTALOX5MAOBMEN1KMT2A | |
| SCHEMBL29405771 | 0.71 | ALOX5 (0.57) | MAPTALOX5MAOBMEN1KMT2A | |
| SCHEMBL31576808 | 0.70 | RIPK2 (0.47) | MAPTMAPK1ALOX5MAOBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994093-B1 | POLYHYDROXYPHENOL DERIVATIVES AND PREVENTIVE AND THERAPEUTIC AGENTS FOR BONE AND CARTILAGE DISEASES CONTAINING THE SAME | HOECHST MARION ROUSSEL LTD (JP) | 2005-12-28 | — | — | EP | claimed |
| US-6177474-B1 | AROMATIC COMPOUND CONTAINING KETONE AND HYDROXY GROUPS | HOECHST MARION ROUSSEL (FR) | 2001-01-23 | — | — | US | claimed |
| EP-0994093-A1 | POLYHYDROXYPHENOL DERIVATIVES AND PREVENTIVE AND THERAPEUTIC AGENTS FOR BONE AND CARTILAGE DISEASES CONTAINING THE SAME | Hoechst Marion Roussel, Ltd. (JP) | 2000-04-19 | — | — | EP | claimed |
| EP-0994093-B1 | POLYHYDROXYPHENOL DERIVATIVES AND PREVENTIVE AND THERAPEUTIC AGENTS FOR BONE AND CARTILAGE DISEASES CONTAINING THE SAME | HOECHST MARION ROUSSEL LTD (JP) | 2005-12-28 | — | — | EP | disclosed |
| US-6177474-B1 | AROMATIC COMPOUND CONTAINING KETONE AND HYDROXY GROUPS | HOECHST MARION ROUSSEL (FR) | 2001-01-23 | — | — | US | disclosed |
| EP-0994093-A1 | POLYHYDROXYPHENOL DERIVATIVES AND PREVENTIVE AND THERAPEUTIC AGENTS FOR BONE AND CARTILAGE DISEASES CONTAINING THE SAME | Hoechst Marion Roussel, Ltd. (JP) | 2000-04-19 | — | — | EP | disclosed |