Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 13/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PKLR | P30613 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624777 | 0.89 | NR1I2 (0.43) | TRPV3GRIN1GRIN2AGRIN2BNR1I2 | |
| SCHEMBL627086 | 0.84 | GRIN1 (0.49) | TRPV3GRIN1GRIN2AGRIN2BNR1I2 | |
| SCHEMBL624452 | 0.76 | NR1I2 (0.59) | TRPV3NR1I2HDAC6HDAC3HDAC1 | |
| SCHEMBL624615 | 0.76 | TRPV3 (0.46) | TRPV3HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL624825 | 0.75 | NR1I2 (0.57) | TRPV3NR1I2 | |
| SCHEMBL14893409 | 0.74 | NR1I2 (0.39) | TRPV3NR1I2HDAC6HDAC3HDAC1 | |
| SCHEMBL625376 | 0.71 | TRPV3 (0.43) | TRPV3NR1I2HDAC6HDAC3HDAC1 | |
| SCHEMBL624746 | 0.71 | TRPV3 (0.49) | TRPV3NR1I2HDAC6HDAC3HDAC1 | |
| SCHEMBL624514 | 0.71 | TRPV3 (0.43) | TRPV3NR1I2HDAC6HDAC3HDAC1 | |
| SCHEMBL624513 | 0.71 | TRPV3 (0.43) | TRPV3NR1I2HDAC6HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |