Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.40 |
| ▸ | GPR3 | P46089 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624777 | 0.86 | NR1I2 (0.43) | GRIN1GRIN2AGRIN2BTRPV3CETP | |
| SCHEMBL627085 | 0.84 | TRPV3 (0.38) | GRIN1GRIN2AGRIN2BTRPV3CETP | |
| SCHEMBL624615 | 0.77 | TRPV3 (0.46) | TRPV3CYP2C9CYP2C19ALDH1A1HDAC6 | |
| SCHEMBL624513 | 0.75 | TRPV3 (0.43) | TRPV3NR1I2HDAC6 | |
| SCHEMBL624514 | 0.75 | TRPV3 (0.43) | TRPV3NR1I2HDAC6 | |
| SCHEMBL625376 | 0.75 | TRPV3 (0.43) | TRPV3NR1I2HDAC6 | |
| SCHEMBL624825 | 0.74 | NR1I2 (0.57) | TRPV3NR1I2 | |
| SCHEMBL624452 | 0.74 | NR1I2 (0.59) | TRPV3CETPNR1I2HDAC6 | |
| SCHEMBL624746 | 0.72 | TRPV3 (0.49) | TRPV3CYP17A1NR1I2HDAC6 | |
| SCHEMBL14893409 | 0.71 | NR1I2 (0.39) | TRPV3CETPNR1I2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2603490-A1 | NOVEL TRPV3 MODULATORS | AbbVie Inc. (US) | 2013-06-19 | — | — | EP | disclosed |
| WO-2012019315-A1 | NOVEL TRPV3 MODULATORS | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | WO | disclosed |