Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 3/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1362496 | 0.91 | GAA (0.39) | GAACASRTACR1TACR3GPR88 | |
| SCHEMBL6266202 | 0.88 | SMN1; SMN2 (0.51) | GAAHTTSMN1; SMN2 | |
| SCHEMBL6156983 | 0.79 | CYP3A4 (0.48) | TACR1TACR3 | |
| SCHEMBL1361676 | 0.79 | SMN1; SMN2 (0.51) | GAAHTTSMN1; SMN2 | |
| SCHEMBL6157147 | 0.77 | TACR1 (0.55) | TACR1TACR3GPR88 | |
| SCHEMBL6617401 | 0.77 | ACE (0.46) | — | |
| SCHEMBL2945636 | 0.74 | MME (0.48) | — | |
| SCHEMBL5741003 | 0.74 | CNR1 (0.39) | TACR1TACR3 | |
| SCHEMBL6156432 | 0.71 | MMP1 (0.45) | — | |
| SCHEMBL6156498 | 0.71 | CTSS (0.41) | TACR1TACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597245-A1 | BENZOTHIAZEPINE AND BENZOTHIEPINE DERIVATIVES | AstraZeneca AB (SE) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004076430-A1 | BENZOTHIAZEPINE AND BENZOTHIEPINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-09-10 | — | — | WO | disclosed |