Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 2/20 | 0.80 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.83 |
| ▸ | LMNA | P02545 | 2/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.80 |
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | SPR | P35270 | 4/20 | 0.65 |
| ▸ | BLM | P54132 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | IDO1 | P14902 | 1/20 | 0.65 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.60 |
| ▸ | MPO | P05164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6271100 | 1.00 | NPSR1 (0.83) | NPSR1KDM4EALDH1A1LMNATDP1 | |
| Oxalic Acid SCHEMBL1320479 | 0.91 | KDM4E (1.00) | NPSR1KDM4EALDH1A1LMNATDP1 | |
| SCHEMBL1127784 | 0.89 | HTR2C (1.00) | NPSR1KDM4EALDH1A1LMNATDP1 | |
| SCHEMBL29471374 | 0.89 | HTR2C (1.00) | NPSR1KDM4EALDH1A1LMNATDP1 | |
| Serotonin SCHEMBL7091772 | 0.83 | HTR2C (0.78) | NPSR1KDM4EALDH1A1LMNATDP1 | |
| Serotonin SCHEMBL7091769 | 0.83 | HTR2C (0.78) | NPSR1KDM4EALDH1A1LMNATDP1 | |
| Serotonin SCHEMBL31141325 | 0.83 | HTR2C (0.78) | NPSR1KDM4EALDH1A1LMNATDP1 | |
| Serotonin SCHEMBL1321606 | 0.82 | HTR2C (0.76) | NPSR1KDM4EALDH1A1LMNATDP1 | |
| Serotonin SCHEMBL29042320 | 0.82 | HTR2C (0.76) | NPSR1KDM4EALDH1A1LMNATDP1 | |
| SCHEMBL29693558 | 0.80 | HTR2C (0.81) | NPSR1KDM4EALDH1A1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002038142-A2 | SEROTONERGIC COMPOSITIONS AND METHODS FOR TREATMENT OF MILD COGNITIVE IMPAIRMENT | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2002-05-16 | — | — | WO | claimed |
| CN-106983759-A | Treat the new compositions and method of excess proliferative disease | ALS山地有限责任公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-102098914-A | Novel compositions and methods for treating hyperproliferative diseases | ALS MOUNTAIN LLC | 2011-06-15 | — | — | CN | disclosed |
| WO-2005107473-A2 | TREATING DIGESTIVE TRACT CONDITIONS | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2005-11-17 | — | — | WO | disclosed |
| WO-2002038142-A2 | SEROTONERGIC COMPOSITIONS AND METHODS FOR TREATMENT OF MILD COGNITIVE IMPAIRMENT | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2002-05-16 | — | — | WO | disclosed |
| EP-0555231-A1 | REGULATION OF NEOPLASTIC CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR | MILES INC. (US) | 1993-08-18 | — | — | EP | disclosed |
| EP-0547172-A1 | REGULATION OF T-CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR | MILES INC. (US) | 1993-06-23 | — | — | EP | disclosed |
| WO-1992004015-A2 | REGULATION OF T-CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR | MILES INC. (US) | 1992-03-19 | — | — | WO | disclosed |
| WO-1992004014-A2 | REGULATION OF NEOPLASTIC CELL PROLIFERATION VIA A NOVEL 5HT1a RECEPTOR | MILES INC. (US) | 1992-03-19 | — | — | WO | disclosed |