Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 6/20 | 0.44 |
| ▸ | PIM1 | P11309 | 6/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL624084 | 0.94 | F2RL3 (0.45) | F2RL3PIM1ACP1PIM3PIM2 | |
| SCHEMBL2253772 | 0.91 | ACP1 (0.52) | F2RL3PIM1ACP1PIM3PIM2 | |
| SCHEMBL1944702 | 0.90 | PIM1 (0.55) | F2RL3PIM1ACP1PIM3PIM2 | |
| SCHEMBL625517 | 0.90 | PIM1 (0.47) | F2RL3PIM1ACP1PIM3PIM2 | |
| SCHEMBL623029 | 0.87 | ACKR3 (0.51) | F2RL3PIM1ACP1IRAK4ACKR3 | |
| SCHEMBL1944086 | 0.84 | F2RL3 (0.51) | F2RL3PIM1IRAK4 | |
| SCHEMBL1944572 | 0.82 | SCN9A (0.41) | F2RL3PIM1ACP1IRAK4 | |
| SCHEMBL1945213 | 0.82 | F2RL3 (0.46) | F2RL3PIM1ACP1PIM3PIM2 | |
| SCHEMBL627161 | 0.82 | PIM1 (0.56) | PIM1PIM3PIM2 | |
| SCHEMBL1946084 | 0.81 | F2RL3 (0.45) | F2RL3PIM1ACP1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012020217-A1 | AMINO- IMIDAZOLOTHIADIAZOLES FOR USE AS PROTEIN OR LIPID KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-02-16 | — | — | WO | disclosed |