SCHEMBL627214

SCHEMBL627214

CCCCCNC(N)=NO

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN2D O15399 1/20 0.55
GRIN3B O60391 1/20 0.55
GRIN1 Q05586 1/20 0.55
GRIN2A Q12879 1/20 0.55
GRIN2B Q13224 1/20 0.55
GRIN2C Q14957 1/20 0.55
GRIN3A Q8TCU5 1/20 0.55
SIGMAR1 Q99720 1/20 0.55
SPHK1 Q9NYA1 3/20 0.49
EPHX1 P07099 6/20 0.46
HDAC1 Q13547 1/20 0.43
HDAC2 Q92769 1/20 0.43
NAAA Q02083 1/20 0.43
CASP2 P42575 1/20 0.42
PRCP P42785 1/20 0.42
DPP7 Q9UHL4 1/20 0.41
ALDH1A1 P00352 1/20 0.40
TSHR P16473 1/20 0.40
GNAI3 P08754 1/20 0.40
GNAO1 P09471 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10339979 0.93
SCHEMBL24115232 0.93
SCHEMBL611007 0.93
SCHEMBL14932687 0.82 GRIN2D (0.55) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL4400258 0.82 GRIN2D (0.55) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
Iodide SCHEMBL4399930 0.80 GRIN2D (0.53) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
Bromide SCHEMBL5326686 0.80 GRIN2D (0.53) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL15787136 0.78 CYP2C19 (0.48) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL22622050 0.78 GRIN2D (0.62) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL1273856 0.78 GRIN2D (0.81) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 190 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111135301-A Application of NO and/or NO donor in preparation of medicine for preventing and/or assisting treatment of open-angle glaucoma and medicine 罗辉 2020-05-12 CN claimed
US-9708306-B2 Benzimidazole derivatives and preparation process and pharmaceutical uses thereof WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD (CN) 2017-07-18 US claimed
US-20170022188-A1 Benzimidazole Derivatives and Preparation Process and Pharmaceutical Uses Thereof WUHAN LL SCIENCE AND TECHNOLOGY DEVELOPMENT CO., LTD. (CN) 2017-01-26 US claimed
US-20130123354-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC. (US) 2013-05-16 US claimed
US-20100144864-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC. (US) 2010-06-10 US claimed
WO-2008157537-A2 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC (US) 2008-12-24 WO claimed
WO-2008124505-A2 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS,INC. (US) 2008-10-16 WO claimed
EP-1082112-B1 ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION NITROMED INC (US) 2008-04-09 EP claimed
EP-1242068-A4 ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION NITROMED INC (US) 2007-04-25 EP claimed
EP-1082112-A4 ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION NITROMED INC (US) 2004-06-09 EP claimed
EP-1242068-A1 ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION Nitromed, Inc. (US) 2002-09-25 EP claimed
US-6436997-B1 Endogenous nitric oxide synthesis under conditions of low oxygen tension NITROMED, INC. 2002-08-20 US claimed
US-6277884-B1 Treatment of sexual dysfunction with N-hydroxyguanidine compounds NITROMED, INC. 2001-08-21 US claimed
WO-2001032167-A1 ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION NITROMED, INC. (US) 2001-05-10 WO claimed
EP-1082112-A1 ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION Nitromed, Inc. (US) 2001-03-14 EP claimed
WO-1999062509-A1 ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION NITROMED, INC. (US) 1999-12-09 WO claimed
US-20240228520-A9 PHOSPHORUS PRODRUGS OF PYRAZOLO-SUBSTITUTED PYRIMIDINE SGC STIMULATORS CYCLERION THERAPEUTICS INC (US) 2024-07-11 US disclosed
US-20240208979-A1 sGC STIMULATORS TISENTO THERAPEUTICS INC. 2024-06-27 US disclosed
EP-1082112-A1 ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION Nitromed, Inc. (US) 2001-03-14 EP disclosed
WO-1999062509-A1 ENDOGENOUS NITRIC OXIDE SYNTHESIS UNDER CONDITIONS OF LOW OXYGEN TENSION NITROMED, INC. (US) 1999-12-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170022188-A1 Benzimidazole Derivatives and Preparation Process and Pharmaceutical Uses Thereof REN, CYP3A5, AZI2 GRIN2D 2026/4885GRIN3B 1943/4885GRIN1 1165/4885
US-20240208979-A1 sGC STIMULATORS GMPS, PRKG1, CGAS GRIN2D 3631/4885GRIN3B 1298/4885GRIN1 1405/4885
US-20100144864-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS GUCY1A2, GUCY1B2, GUCY1B1 GRIN2D 3516/4885GRIN3B 1778/4885GRIN1 1434/4885
US-20130123354-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS GUCY1A2, GUCY1B2, GUCY1B1 GRIN2D 3516/4885GRIN3B 1778/4885GRIN1 1434/4885
US-20240228520-A9 PHOSPHORUS PRODRUGS OF PYRAZOLO-SUBSTITUTED PYRIMIDINE SGC STIMULATORS P2RY1, P2RY11, GMPS GRIN2D 2031/4885GRIN3B 946/4885GRIN1 994/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.