Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | FASN | P49327 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6271 | 1.00 | HTT (0.38) | HTTKMT2AMEN1ATMFASN | |
| SCHEMBL5697 | 0.85 | KMT2A (0.41) | HTTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5695 | 0.85 | KMT2A (0.41) | HTTKMT2AMEN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6436 | 0.84 | ATM (0.37) | HTTKMT2AATMFASNF10 | |
| SCHEMBL6438 | 0.84 | ATM (0.37) | HTTKMT2AATMFASNF10 | |
| SCHEMBL6393 | 0.84 | ATM (0.39) | ATMFASNF10KDM1AHPGD | |
| SCHEMBL6395 | 0.84 | ATM (0.39) | ATMFASNF10KDM1AHPGD | |
| SCHEMBL11909676 | 0.82 | HTT (0.42) | HTTKMT2AMEN1MGLLALDH1A1 | |
| SCHEMBL6574 | 0.82 | HTT (0.38) | HTTKMT2AMEN1GAATDP1 | |
| SCHEMBL6572 | 0.82 | HTT (0.38) | HTTKMT2AMEN1GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493310-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GlaxoSmithKline LLC (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056635-A1 | BENZIMIDAZOLES AS FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |