Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | DGKA | P23743 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PAM | P19021 | 2/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515232 | 0.97 | LMNA (0.49) | LMNAMAPTMAPK1DGKAALDH1A1 | |
| SCHEMBL1739619 | 0.92 | LMNA (0.53) | LMNAMAPTMAPK1DGKAALDH1A1 | |
| SCHEMBL15512626 | 0.87 | LMNA (0.50) | LMNAMAPTMAPK1DGKAALDH1A1 | |
| SCHEMBL30760720 | 0.87 | LMNA (0.58) | LMNAMAPTMAPK1DGKAALDH1A1 | |
| SCHEMBL7802146 | 0.87 | LMNA (0.58) | LMNAMAPTMAPK1DGKAALDH1A1 | |
| SCHEMBL8340752 | 0.87 | LMNA (0.58) | LMNAMAPTMAPK1DGKAALDH1A1 | |
| SCHEMBL28745605 | 0.87 | LMNA (0.58) | LMNAMAPTMAPK1DGKAALDH1A1 | |
| SCHEMBL1740609 | 0.87 | LMNA (0.58) | LMNAMAPTMAPK1DGKAALDH1A1 | |
| SCHEMBL22655191 | 0.87 | LMNA (0.58) | LMNAMAPTMAPK1DGKAALDH1A1 | |
| SCHEMBL20544133 | 0.87 | LMNA (0.58) | LMNAMAPTMAPK1DGKAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994093-B1 | POLYHYDROXYPHENOL DERIVATIVES AND PREVENTIVE AND THERAPEUTIC AGENTS FOR BONE AND CARTILAGE DISEASES CONTAINING THE SAME | HOECHST MARION ROUSSEL LTD (JP) | 2005-12-28 | — | — | EP | disclosed |
| US-6177474-B1 | AROMATIC COMPOUND CONTAINING KETONE AND HYDROXY GROUPS | HOECHST MARION ROUSSEL (FR) | 2001-01-23 | — | — | US | disclosed |
| EP-0994093-A1 | POLYHYDROXYPHENOL DERIVATIVES AND PREVENTIVE AND THERAPEUTIC AGENTS FOR BONE AND CARTILAGE DISEASES CONTAINING THE SAME | Hoechst Marion Roussel, Ltd. (JP) | 2000-04-19 | — | — | EP | disclosed |