Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6273143 | 1.00 | SNCA (0.39) | SNCARAB9AMAOBAPPKDM4E | |
| SCHEMBL6272573 | 0.80 | ABCB1 (0.44) | RAB9AMAOBMAPT | |
| SCHEMBL6272578 | 0.80 | ABCB1 (0.44) | RAB9AMAOBMAPT | |
| SCHEMBL6272560 | 0.79 | THRB (0.45) | RAB9AMAOBKDM4ENPC1ALDH1A1 | |
| SCHEMBL6278229 | 0.79 | CD74 (0.33) | RAB9AMAOBNPC1ALDH1A1MAPT | |
| SCHEMBL6274709 | 0.76 | MAPT (0.46) | MAOBMAPT | |
| SCHEMBL6274180 | 0.76 | THRB (0.42) | RAB9AMAOBKDM4ENPC1ALDH1A1 | |
| SCHEMBL6274175 | 0.76 | THRB (0.42) | RAB9AMAOBKDM4ENPC1ALDH1A1 | |
| SCHEMBL6275956 | 0.71 | NPC1 (0.46) | RAB9AMAOBAPPNPC1POLB | |
| SCHEMBL6275960 | 0.71 | NPC1 (0.46) | RAB9AMAOBAPPNPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005116010-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | MERCK FROSST CANADA LTD. (CA) | 2005-12-08 | — | — | WO | disclosed |